Cargando…

Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex

The medial prefrontal cortex (mPFC) is necessary for executing many learned associations between stimuli and movement. It is unclear, however, how activity in the mPFC evolves across learning, and how this activity correlates with sensory stimuli and the learned movements they evoke. To address thes...

Descripción completa

Detalles Bibliográficos
Autores principales: Peters, Andrew J., Marica, Andrada-Maria, Fabre, Julie M.J., Harris, Kenneth D., Carandini, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631115/
https://www.ncbi.nlm.nih.gov/pubmed/36261004
http://dx.doi.org/10.1016/j.celrep.2022.111487
_version_ 1784823753134309376
author Peters, Andrew J.
Marica, Andrada-Maria
Fabre, Julie M.J.
Harris, Kenneth D.
Carandini, Matteo
author_facet Peters, Andrew J.
Marica, Andrada-Maria
Fabre, Julie M.J.
Harris, Kenneth D.
Carandini, Matteo
author_sort Peters, Andrew J.
collection PubMed
description The medial prefrontal cortex (mPFC) is necessary for executing many learned associations between stimuli and movement. It is unclear, however, how activity in the mPFC evolves across learning, and how this activity correlates with sensory stimuli and the learned movements they evoke. To address these questions, we record cortical activity with widefield calcium imaging while mice learned to associate a visual stimulus with a forelimb movement. After learning, the mPFC shows stimulus-evoked activity both during task performance and during passive viewing, when the stimulus evokes no action. This stimulus-evoked activity closely tracks behavioral performance across training, with both exhibiting a marked increase between days when mice first learn the task, followed by a steady increase with further training. Electrophysiological recordings localized this activity to the secondary motor and anterior cingulate cortex. We conclude that learning a visuomotor task promotes a route for visual information to reach the prefrontal cortex.
format Online
Article
Text
id pubmed-9631115
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cell Press
record_format MEDLINE/PubMed
spelling pubmed-96311152022-11-07 Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex Peters, Andrew J. Marica, Andrada-Maria Fabre, Julie M.J. Harris, Kenneth D. Carandini, Matteo Cell Rep Report The medial prefrontal cortex (mPFC) is necessary for executing many learned associations between stimuli and movement. It is unclear, however, how activity in the mPFC evolves across learning, and how this activity correlates with sensory stimuli and the learned movements they evoke. To address these questions, we record cortical activity with widefield calcium imaging while mice learned to associate a visual stimulus with a forelimb movement. After learning, the mPFC shows stimulus-evoked activity both during task performance and during passive viewing, when the stimulus evokes no action. This stimulus-evoked activity closely tracks behavioral performance across training, with both exhibiting a marked increase between days when mice first learn the task, followed by a steady increase with further training. Electrophysiological recordings localized this activity to the secondary motor and anterior cingulate cortex. We conclude that learning a visuomotor task promotes a route for visual information to reach the prefrontal cortex. Cell Press 2022-10-18 /pmc/articles/PMC9631115/ /pubmed/36261004 http://dx.doi.org/10.1016/j.celrep.2022.111487 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Report
Peters, Andrew J.
Marica, Andrada-Maria
Fabre, Julie M.J.
Harris, Kenneth D.
Carandini, Matteo
Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
title Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
title_full Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
title_fullStr Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
title_full_unstemmed Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
title_short Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
title_sort visuomotor learning promotes visually evoked activity in the medial prefrontal cortex
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631115/
https://www.ncbi.nlm.nih.gov/pubmed/36261004
http://dx.doi.org/10.1016/j.celrep.2022.111487
work_keys_str_mv AT petersandrewj visuomotorlearningpromotesvisuallyevokedactivityinthemedialprefrontalcortex
AT maricaandradamaria visuomotorlearningpromotesvisuallyevokedactivityinthemedialprefrontalcortex
AT fabrejuliemj visuomotorlearningpromotesvisuallyevokedactivityinthemedialprefrontalcortex
AT harriskennethd visuomotorlearningpromotesvisuallyevokedactivityinthemedialprefrontalcortex
AT carandinimatteo visuomotorlearningpromotesvisuallyevokedactivityinthemedialprefrontalcortex