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Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study
PURPOSE: This study evaluated the association between metabolic health status and incident kidney cancer among obese participants. MATERIALS AND METHODS: A total of 514,866 individuals were included from the Korean National Health Insurance Service-National Health Screening Cohort. Changes in metabo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631209/ https://www.ncbi.nlm.nih.gov/pubmed/36339433 http://dx.doi.org/10.3389/fendo.2022.976056 |
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author | Cho, Yun Kyung Kim, Hwi Seung Park, Joong-Yeol Lee, Woo Je Kim, Ye-Jee Jung, Chang Hee |
author_facet | Cho, Yun Kyung Kim, Hwi Seung Park, Joong-Yeol Lee, Woo Je Kim, Ye-Jee Jung, Chang Hee |
author_sort | Cho, Yun Kyung |
collection | PubMed |
description | PURPOSE: This study evaluated the association between metabolic health status and incident kidney cancer among obese participants. MATERIALS AND METHODS: A total of 514,866 individuals were included from the Korean National Health Insurance Service-National Health Screening Cohort. Changes in metabolic health status and obesity from the baseline examination in 2009–2010 to the next biannual examination in 2011–2012 were determined. Based on the status change, obese participants were divided into four groups: stable metabolically healthy obesity, metabolically healthy obesity to metabolically unhealthy obesity, metabolically unhealthy obesity to metabolically healthy obesity, and stable metabolically unhealthy obesity. RESULTS: The stable metabolically healthy obesity phenotype did not confer an increased risk of incident kidney cancer, compared to the stable metabolically healthy non-obese group. In contrast, the metabolically healthy obesity to metabolically unhealthy obesity group had a significantly higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. Among patients with metabolically unhealthy obesity at baseline, those who transitioned to the metabolically healthy obese group had no increased risk of kidney cancer, whereas those who remained in metabolically unhealthy obesity status had a higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. The transition or maintenance of metabolic health was a decisive factor for kidney cancer in obese patients. CONCLUSIONS: Maintaining or restoring metabolic health should be stressed upon in obese patients to reduce the risk of kidney cancer. |
format | Online Article Text |
id | pubmed-9631209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96312092022-11-04 Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study Cho, Yun Kyung Kim, Hwi Seung Park, Joong-Yeol Lee, Woo Je Kim, Ye-Jee Jung, Chang Hee Front Endocrinol (Lausanne) Endocrinology PURPOSE: This study evaluated the association between metabolic health status and incident kidney cancer among obese participants. MATERIALS AND METHODS: A total of 514,866 individuals were included from the Korean National Health Insurance Service-National Health Screening Cohort. Changes in metabolic health status and obesity from the baseline examination in 2009–2010 to the next biannual examination in 2011–2012 were determined. Based on the status change, obese participants were divided into four groups: stable metabolically healthy obesity, metabolically healthy obesity to metabolically unhealthy obesity, metabolically unhealthy obesity to metabolically healthy obesity, and stable metabolically unhealthy obesity. RESULTS: The stable metabolically healthy obesity phenotype did not confer an increased risk of incident kidney cancer, compared to the stable metabolically healthy non-obese group. In contrast, the metabolically healthy obesity to metabolically unhealthy obesity group had a significantly higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. Among patients with metabolically unhealthy obesity at baseline, those who transitioned to the metabolically healthy obese group had no increased risk of kidney cancer, whereas those who remained in metabolically unhealthy obesity status had a higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. The transition or maintenance of metabolic health was a decisive factor for kidney cancer in obese patients. CONCLUSIONS: Maintaining or restoring metabolic health should be stressed upon in obese patients to reduce the risk of kidney cancer. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9631209/ /pubmed/36339433 http://dx.doi.org/10.3389/fendo.2022.976056 Text en Copyright © 2022 Cho, Kim, Park, Lee, Kim and Jung https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Cho, Yun Kyung Kim, Hwi Seung Park, Joong-Yeol Lee, Woo Je Kim, Ye-Jee Jung, Chang Hee Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
title | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
title_full | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
title_fullStr | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
title_full_unstemmed | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
title_short | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
title_sort | implications of metabolic health status and obesity on the risk of kidney cancer: a nationwide population-based cohort study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631209/ https://www.ncbi.nlm.nih.gov/pubmed/36339433 http://dx.doi.org/10.3389/fendo.2022.976056 |
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