Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utilized to release the active parent drug at a particul...

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Detalles Bibliográficos
Autores principales: Hugele, Agathe, Löffler, Susanne, Molina, Belén Hernández, Guillon, Melina, Montaser, Ahmed B., Auriola, Seppo, Huttunen, Kristiina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631218/
https://www.ncbi.nlm.nih.gov/pubmed/36339537
http://dx.doi.org/10.3389/fphar.2022.1034964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631218/
https://www.ncbi.nlm.nih.gov/pubmed/36339537
http://dx.doi.org/10.3389/fphar.2022.1034964

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