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Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utilized to release the active parent drug at a particul...

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Detalles Bibliográficos
Autores principales:	Hugele, Agathe, Löffler, Susanne, Molina, Belén Hernández, Guillon, Melina, Montaser, Ahmed B., Auriola, Seppo, Huttunen, Kristiina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631218/ https://www.ncbi.nlm.nih.gov/pubmed/36339537 http://dx.doi.org/10.3389/fphar.2022.1034964

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