Cargando…
Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus
Pemphigus vulgaris is a rare autoimmune skin disease. Although herpes simplex virus has been associated with autoimmune diseases, evidence regarding its association with pemphigus vulgaris exacerbations is scarce. This retrospective cohort study aimed to characterize the epidemiological and clinical...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Publication of Acta Dermato-Venereologica
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631263/ https://www.ncbi.nlm.nih.gov/pubmed/35393625 http://dx.doi.org/10.2340/actadv.v102.917 |
_version_ | 1784823780066983936 |
---|---|
author | BAUM, Sharon ATAR, Itai COSTER, Dan DOVRAT, Sara SOLOMON, Michal SPRECHER, Eli ZEELI, Tal BARZILAI, Aviv |
author_facet | BAUM, Sharon ATAR, Itai COSTER, Dan DOVRAT, Sara SOLOMON, Michal SPRECHER, Eli ZEELI, Tal BARZILAI, Aviv |
author_sort | BAUM, Sharon |
collection | PubMed |
description | Pemphigus vulgaris is a rare autoimmune skin disease. Although herpes simplex virus has been associated with autoimmune diseases, evidence regarding its association with pemphigus vulgaris exacerbations is scarce. This retrospective cohort study aimed to characterize the epidemiological and clinical features of patients with pemphigus vulgaris who were herpes simplex-positive, compared with those who were herpes simplex-negative, during disease onset. Of 62 patients with pemphigus vulgaris who underwent PCR testing for herpes simplex virus, 25 (40.3%) were positive, with a mean age of 56.1 ± 15.5 years; 35.5% were male. The herpes-positive group had significantly elevated levels of C-reactive protein, Pemphigus Disease Activity Index score, and shorter time to relapse. The time to remission, number of exacerbations per year, and remission status were non-significantly elevated in the herpes-positive group. Thus, routine testing lesions from patients with pemphigus for herpes simplex virus should be performed. If positive, antiviral treatment should be initiated; and preventive antiviral treatment should be considered in severe cases. |
format | Online Article Text |
id | pubmed-9631263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-96312632022-11-17 Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus BAUM, Sharon ATAR, Itai COSTER, Dan DOVRAT, Sara SOLOMON, Michal SPRECHER, Eli ZEELI, Tal BARZILAI, Aviv Acta Derm Venereol Original Article Pemphigus vulgaris is a rare autoimmune skin disease. Although herpes simplex virus has been associated with autoimmune diseases, evidence regarding its association with pemphigus vulgaris exacerbations is scarce. This retrospective cohort study aimed to characterize the epidemiological and clinical features of patients with pemphigus vulgaris who were herpes simplex-positive, compared with those who were herpes simplex-negative, during disease onset. Of 62 patients with pemphigus vulgaris who underwent PCR testing for herpes simplex virus, 25 (40.3%) were positive, with a mean age of 56.1 ± 15.5 years; 35.5% were male. The herpes-positive group had significantly elevated levels of C-reactive protein, Pemphigus Disease Activity Index score, and shorter time to relapse. The time to remission, number of exacerbations per year, and remission status were non-significantly elevated in the herpes-positive group. Thus, routine testing lesions from patients with pemphigus for herpes simplex virus should be performed. If positive, antiviral treatment should be initiated; and preventive antiviral treatment should be considered in severe cases. Society for Publication of Acta Dermato-Venereologica 2022-05-04 /pmc/articles/PMC9631263/ /pubmed/35393625 http://dx.doi.org/10.2340/actadv.v102.917 Text en © 2022 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Original Article BAUM, Sharon ATAR, Itai COSTER, Dan DOVRAT, Sara SOLOMON, Michal SPRECHER, Eli ZEELI, Tal BARZILAI, Aviv Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus |
title | Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus |
title_full | Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus |
title_fullStr | Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus |
title_full_unstemmed | Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus |
title_short | Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus |
title_sort | relationship between pemphigus vulgaris severity and pcr-positive herpes simplex virus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631263/ https://www.ncbi.nlm.nih.gov/pubmed/35393625 http://dx.doi.org/10.2340/actadv.v102.917 |
work_keys_str_mv | AT baumsharon relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT ataritai relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT costerdan relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT dovratsara relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT solomonmichal relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT sprechereli relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT zeelital relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus AT barzilaiaviv relationshipbetweenpemphigusvulgarisseverityandpcrpositiveherpessimplexvirus |