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Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck
Guidelines for cutaneous squamous cell carcinoma of the head and neck do not take the age of the patient into account, but instead assume equal tumour characteristics and prognostic factors for poor outcome in younger and elderly patients. The aim of this study was to compare tumour characteristics...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Society for Publication of Acta Dermato-Venereologica
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631266/ https://www.ncbi.nlm.nih.gov/pubmed/34935990 http://dx.doi.org/10.2340/actadv.v101.347 |
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author | LEUS, Alet J. G. HAISMA, Marjolijn S. TERRA, Jorrit B. DIERCKS, Gilles F. H. VAN KESTER, Marloes S. HALMOS, Gyuri B. RÁCZ, Emöke VAN DIJK, Boukje A. C. PLAAT, Boudewijn E. C. |
author_facet | LEUS, Alet J. G. HAISMA, Marjolijn S. TERRA, Jorrit B. DIERCKS, Gilles F. H. VAN KESTER, Marloes S. HALMOS, Gyuri B. RÁCZ, Emöke VAN DIJK, Boukje A. C. PLAAT, Boudewijn E. C. |
author_sort | LEUS, Alet J. G. |
collection | PubMed |
description | Guidelines for cutaneous squamous cell carcinoma of the head and neck do not take the age of the patient into account, but instead assume equal tumour characteristics and prognostic factors for poor outcome in younger and elderly patients. The aim of this study was to compare tumour characteristics of younger (< 75 years) and elderly (≥ 75 years) patients and identify age-specific risk factors for progression of disease, comprising local recurrence, nodal metastasis and distant metastasis. Patient and tumour characteristics were compared using χ(2) or Fisher’s exact tests. Multivariable competing risk analyses were performed to compare risk factors for progression of disease, incorporating the risk of dying before developing progression of disease. A total of 672 patients with primary cutaneous squamous cell carcinoma of the head and neck were retrospectively included. Larger tumour diameter, worse differentiation grade and deeper invasion were observed in older patients. In elderly patients, but not in younger patients, tumour diameter ≥ 40 mm, moderate differentiation grade and an invasion depth ≥ 2 mm were independent risk factors for progression of disease. |
format | Online Article Text |
id | pubmed-9631266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-96312662022-11-17 Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck LEUS, Alet J. G. HAISMA, Marjolijn S. TERRA, Jorrit B. DIERCKS, Gilles F. H. VAN KESTER, Marloes S. HALMOS, Gyuri B. RÁCZ, Emöke VAN DIJK, Boukje A. C. PLAAT, Boudewijn E. C. Acta Derm Venereol Original Article Guidelines for cutaneous squamous cell carcinoma of the head and neck do not take the age of the patient into account, but instead assume equal tumour characteristics and prognostic factors for poor outcome in younger and elderly patients. The aim of this study was to compare tumour characteristics of younger (< 75 years) and elderly (≥ 75 years) patients and identify age-specific risk factors for progression of disease, comprising local recurrence, nodal metastasis and distant metastasis. Patient and tumour characteristics were compared using χ(2) or Fisher’s exact tests. Multivariable competing risk analyses were performed to compare risk factors for progression of disease, incorporating the risk of dying before developing progression of disease. A total of 672 patients with primary cutaneous squamous cell carcinoma of the head and neck were retrospectively included. Larger tumour diameter, worse differentiation grade and deeper invasion were observed in older patients. In elderly patients, but not in younger patients, tumour diameter ≥ 40 mm, moderate differentiation grade and an invasion depth ≥ 2 mm were independent risk factors for progression of disease. Society for Publication of Acta Dermato-Venereologica 2022-02-22 /pmc/articles/PMC9631266/ /pubmed/34935990 http://dx.doi.org/10.2340/actadv.v101.347 Text en © 2022 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Original Article LEUS, Alet J. G. HAISMA, Marjolijn S. TERRA, Jorrit B. DIERCKS, Gilles F. H. VAN KESTER, Marloes S. HALMOS, Gyuri B. RÁCZ, Emöke VAN DIJK, Boukje A. C. PLAAT, Boudewijn E. C. Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck |
title | Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck |
title_full | Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck |
title_fullStr | Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck |
title_full_unstemmed | Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck |
title_short | Age-related Differences in Tumour Characteristics and Prognostic Factors for Disease Progression in Cutaneous Squamous Cell Carcinoma of the Head and Neck |
title_sort | age-related differences in tumour characteristics and prognostic factors for disease progression in cutaneous squamous cell carcinoma of the head and neck |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631266/ https://www.ncbi.nlm.nih.gov/pubmed/34935990 http://dx.doi.org/10.2340/actadv.v101.347 |
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