One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles

[Image: see text] A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding N-(o-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably...

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Detalles Bibliográficos
Autores principales: Sterligov, Grigorii K., Ageshina, Alexandra A., Rzhevskiy, Sergey A., Shurupova, Olga V., Topchiy, Maxim A., Minaeva, Lidiya I., Asachenko, Andrey F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631411/
https://www.ncbi.nlm.nih.gov/pubmed/36340104
http://dx.doi.org/10.1021/acsomega.2c03754
Descripción
Sumario:[Image: see text] A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding N-(o-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably substituted indoles in good yields from readily available starting materials.

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