One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles

[Image: see text] A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding N-(o-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably...

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Autores principales: Sterligov, Grigorii K., Ageshina, Alexandra A., Rzhevskiy, Sergey A., Shurupova, Olga V., Topchiy, Maxim A., Minaeva, Lidiya I., Asachenko, Andrey F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631411/
https://www.ncbi.nlm.nih.gov/pubmed/36340104
http://dx.doi.org/10.1021/acsomega.2c03754
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author Sterligov, Grigorii K.
Ageshina, Alexandra A.
Rzhevskiy, Sergey A.
Shurupova, Olga V.
Topchiy, Maxim A.
Minaeva, Lidiya I.
Asachenko, Andrey F.
author_facet Sterligov, Grigorii K.
Ageshina, Alexandra A.
Rzhevskiy, Sergey A.
Shurupova, Olga V.
Topchiy, Maxim A.
Minaeva, Lidiya I.
Asachenko, Andrey F.
author_sort Sterligov, Grigorii K.
collection PubMed
description [Image: see text] A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding N-(o-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably substituted indoles in good yields from readily available starting materials.
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spelling pubmed-96314112022-11-04 One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles Sterligov, Grigorii K. Ageshina, Alexandra A. Rzhevskiy, Sergey A. Shurupova, Olga V. Topchiy, Maxim A. Minaeva, Lidiya I. Asachenko, Andrey F. ACS Omega [Image: see text] A One-pot, two-step procedure for the synthesis of 1,2-disubstituted-3-tosyl and 1,2-disubstituted-3-cyanoindoles from the corresponding N-(o-tolyl)benzamides is reported. The developed procedure is operationally simple, does not utilize any transition metals, and provides variably substituted indoles in good yields from readily available starting materials. American Chemical Society 2022-10-19 /pmc/articles/PMC9631411/ /pubmed/36340104 http://dx.doi.org/10.1021/acsomega.2c03754 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Sterligov, Grigorii K.
Ageshina, Alexandra A.
Rzhevskiy, Sergey A.
Shurupova, Olga V.
Topchiy, Maxim A.
Minaeva, Lidiya I.
Asachenko, Andrey F.
One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
title One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
title_full One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
title_fullStr One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
title_full_unstemmed One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
title_short One-Pot Modified Madelung Synthesis of 3-Tosyl- and 3-Cyano-1,2-disubstituted Indoles
title_sort one-pot modified madelung synthesis of 3-tosyl- and 3-cyano-1,2-disubstituted indoles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631411/
https://www.ncbi.nlm.nih.gov/pubmed/36340104
http://dx.doi.org/10.1021/acsomega.2c03754
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