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Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application

Metastasis is one of the important biological features of malignant tumors and one of the main factors responsible for poor prognosis. Although the widespread application of newer clinical technologies and their continuous development have significantly improved survival in patients with brain metas...

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Autores principales: Aili, Yirizhati, Maimaitiming, Nuersimanguli, Qin, Hu, Ji, Wenyu, Fan, Guofeng, Wang, Zengliang, Wang, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631487/
https://www.ncbi.nlm.nih.gov/pubmed/36338717
http://dx.doi.org/10.3389/fonc.2022.983878
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author Aili, Yirizhati
Maimaitiming, Nuersimanguli
Qin, Hu
Ji, Wenyu
Fan, Guofeng
Wang, Zengliang
Wang, Yongxin
author_facet Aili, Yirizhati
Maimaitiming, Nuersimanguli
Qin, Hu
Ji, Wenyu
Fan, Guofeng
Wang, Zengliang
Wang, Yongxin
author_sort Aili, Yirizhati
collection PubMed
description Metastasis is one of the important biological features of malignant tumors and one of the main factors responsible for poor prognosis. Although the widespread application of newer clinical technologies and their continuous development have significantly improved survival in patients with brain metastases, there is no uniform standard of care. More effective therapeutic measures are therefore needed to improve prognosis. Understanding the mechanisms of tumor cell colonization, growth, and invasion in the central nervous system is of particular importance for the prevention and treatment of brain metastases. This process can be plausibly explained by the “seed and soil” hypothesis, which essentially states that tumor cells can interact with various components of the central nervous system microenvironment to produce adaptive changes; it is this interaction that determines the development of brain metastases. As a novel form of intercellular communication, exosomes play a key role in the brain metastasis microenvironment and carry various bioactive molecules that regulate receptor cell activity. In this paper, we review the roles and prospects of brain metastatic tumor cells, the brain metastatic tumor microenvironment, and exosomes in the development and clinical management of brain metastases.
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spelling pubmed-96314872022-11-04 Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application Aili, Yirizhati Maimaitiming, Nuersimanguli Qin, Hu Ji, Wenyu Fan, Guofeng Wang, Zengliang Wang, Yongxin Front Oncol Oncology Metastasis is one of the important biological features of malignant tumors and one of the main factors responsible for poor prognosis. Although the widespread application of newer clinical technologies and their continuous development have significantly improved survival in patients with brain metastases, there is no uniform standard of care. More effective therapeutic measures are therefore needed to improve prognosis. Understanding the mechanisms of tumor cell colonization, growth, and invasion in the central nervous system is of particular importance for the prevention and treatment of brain metastases. This process can be plausibly explained by the “seed and soil” hypothesis, which essentially states that tumor cells can interact with various components of the central nervous system microenvironment to produce adaptive changes; it is this interaction that determines the development of brain metastases. As a novel form of intercellular communication, exosomes play a key role in the brain metastasis microenvironment and carry various bioactive molecules that regulate receptor cell activity. In this paper, we review the roles and prospects of brain metastatic tumor cells, the brain metastatic tumor microenvironment, and exosomes in the development and clinical management of brain metastases. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9631487/ /pubmed/36338717 http://dx.doi.org/10.3389/fonc.2022.983878 Text en Copyright © 2022 Aili, Maimaitiming, Qin, Ji, Fan, Wang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Aili, Yirizhati
Maimaitiming, Nuersimanguli
Qin, Hu
Ji, Wenyu
Fan, Guofeng
Wang, Zengliang
Wang, Yongxin
Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
title Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
title_full Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
title_fullStr Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
title_full_unstemmed Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
title_short Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application
title_sort tumor microenvironment and exosomes in brain metastasis: molecular mechanisms and clinical application
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631487/
https://www.ncbi.nlm.nih.gov/pubmed/36338717
http://dx.doi.org/10.3389/fonc.2022.983878
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