Metformin for treatment of cytopenias in children and young adults with Fanconi anemia

Fanconi anemia (FA), a genetic DNA repair disorder characterized by marrow failure and cancer susceptibility. In FA mice, metformin improves blood counts and delays tumor development. We conducted a single institution study of metformin in nondiabetic patients with FA to determine feasibility and to...

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Detalles Bibliográficos
Autores principales: Pollard, Jessica A., Furutani, Elissa, Liu, Shanshan, Esrick, Erica, Cohen, Laurie E., Bledsoe, Jacob, Liu, Chih-Wei, Lu, Kun, de Haro, Maria Jose Ramirez, Surrallés, Jordi, Malsch, Maggie, Kuniholm, Ashley, Galvin, Ashley, Armant, Myriam, Kim, Annette S., Ballotti, Kaitlyn, Moreau, Lisa, Zhou, Yu, Babushok, Daria, Boulad, Farid, Carroll, Clint, Hartung, Helge, Hont, Amy, Nakano, Taizo, Olson, Tim, Sze, Sei-Gyung, Thompson, Alexis A., Wlodarski, Marcin W., Gu, Xuesong, Libermann, Towia A., D’Andrea, Alan, Grompe, Markus, Weller, Edie, Shimamura, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Clinical Trials and Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631552/
https://www.ncbi.nlm.nih.gov/pubmed/35500223
http://dx.doi.org/10.1182/bloodadvances.2021006490

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