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Using stroma-anchoring cytokines to augment ADCC: a phase 1 trial of F16IL2 and BI 836858 for posttransplant AML relapse

Natural killer (NK) cells are key effectors in cancer immunosurveillance and posttransplant immunity, but deficiency of environmental signals and insufficient tumor recognition may limit their activity. We hypothesized that the antibody-mediated anchoring of interleukin-2 (IL-2) to a spliced isoform...

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Detalles Bibliográficos
Autores principales:	Berdel, Andrew F., Ruhnke, Leo, Angenendt, Linus, Wermke, Martin, Röllig, Christoph, Mikesch, Jan-Henrik, Scheller, Annika, Hemmerle, Teresa, Matasci, Mattia, Wethmar, Klaus, Kessler, Torsten, Gerwing, Mirjam, Hescheler, Daniel, Schäfers, Michael, Hartmann, Wolfgang, Altvater, Bianca, Rossig, Claudia, Bornhäuser, Martin, Lenz, Georg, Stelljes, Matthias, Rueter, Bjoern, Neri, Dario, Berdel, Wolfgang E., Schliemann, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2022
Materias:	Immunobiology and Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631576/ https://www.ncbi.nlm.nih.gov/pubmed/35468621 http://dx.doi.org/10.1182/bloodadvances.2021006909

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