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Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma

Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite stu...

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Autores principales: O’Donnell, Elizabeth K., Shapiro, Yael N., Yee, Andrew J., Nadeem, Omar, Laubach, Jacob P., Branagan, Andrew R., Anderson, Kenneth C., Mo, Clifton C., Munshi, Nikhil C., Ghobrial, Irene M., Sperling, Adam S., Agyemang, Emerentia A., Burke, Jill N., Harrington, Cynthia C., Hu, Bonnie Y., Richardson, Paul G., Raje, Noopur S., El-Jawahri, Areej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631626/
https://www.ncbi.nlm.nih.gov/pubmed/35848842
http://dx.doi.org/10.1182/bloodadvances.2022007127
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author O’Donnell, Elizabeth K.
Shapiro, Yael N.
Yee, Andrew J.
Nadeem, Omar
Laubach, Jacob P.
Branagan, Andrew R.
Anderson, Kenneth C.
Mo, Clifton C.
Munshi, Nikhil C.
Ghobrial, Irene M.
Sperling, Adam S.
Agyemang, Emerentia A.
Burke, Jill N.
Harrington, Cynthia C.
Hu, Bonnie Y.
Richardson, Paul G.
Raje, Noopur S.
El-Jawahri, Areej
author_facet O’Donnell, Elizabeth K.
Shapiro, Yael N.
Yee, Andrew J.
Nadeem, Omar
Laubach, Jacob P.
Branagan, Andrew R.
Anderson, Kenneth C.
Mo, Clifton C.
Munshi, Nikhil C.
Ghobrial, Irene M.
Sperling, Adam S.
Agyemang, Emerentia A.
Burke, Jill N.
Harrington, Cynthia C.
Hu, Bonnie Y.
Richardson, Paul G.
Raje, Noopur S.
El-Jawahri, Areej
author_sort O’Donnell, Elizabeth K.
collection PubMed
description Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite study of patients undergoing treatment with MM and their caregivers. Eligible caregivers were enrolled to 1 of 3 cohorts based on lines of therapy. Caregivers completed validated questionnaires to assess their QOL, psychological distress, and perceptions of prognosis. We enrolled 127 caregivers of patients with MM (newly diagnosed [n = 43], 2-3 lines of therapy [n = 40], and ≥4 lines of therapy [n = 44]). Caregiver QOL and psychological distress did not differ by line of therapy. The rate of clinically significant anxiety, depression, and posttraumatic stress disorder symptoms were 44.1% (56/127), 15.8% (20/127), and 24.4% (31/127), respectively. When examined in dyads, caregivers reported higher rates of clinically significant anxiety (44.4% [55/124] vs 22.5% [28/124]) compared with patients with MM. Most caregivers (84.2%, 101/120) reported that the oncologist had informed them that the patient’s cancer was incurable; however, only 50.9% (58/114) and 53.6% (59/110) of caregivers acknowledged the patient’s cancer was terminal and incurable, respectively. Caregivers of patients undergoing treatment for MM experience substantial psychological distress across the disease continuum, particularly anxiety. The majority of caregivers of patients with MM report that knowing the patient’s prognosis is extremely important and report that the oncologist told them that the patient was incurable. Nevertheless, a significant portion of caregivers believe that the patient’s MM is curable.
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spelling pubmed-96316262022-11-04 Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma O’Donnell, Elizabeth K. Shapiro, Yael N. Yee, Andrew J. Nadeem, Omar Laubach, Jacob P. Branagan, Andrew R. Anderson, Kenneth C. Mo, Clifton C. Munshi, Nikhil C. Ghobrial, Irene M. Sperling, Adam S. Agyemang, Emerentia A. Burke, Jill N. Harrington, Cynthia C. Hu, Bonnie Y. Richardson, Paul G. Raje, Noopur S. El-Jawahri, Areej Blood Adv Health Services and Outcomes Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite study of patients undergoing treatment with MM and their caregivers. Eligible caregivers were enrolled to 1 of 3 cohorts based on lines of therapy. Caregivers completed validated questionnaires to assess their QOL, psychological distress, and perceptions of prognosis. We enrolled 127 caregivers of patients with MM (newly diagnosed [n = 43], 2-3 lines of therapy [n = 40], and ≥4 lines of therapy [n = 44]). Caregiver QOL and psychological distress did not differ by line of therapy. The rate of clinically significant anxiety, depression, and posttraumatic stress disorder symptoms were 44.1% (56/127), 15.8% (20/127), and 24.4% (31/127), respectively. When examined in dyads, caregivers reported higher rates of clinically significant anxiety (44.4% [55/124] vs 22.5% [28/124]) compared with patients with MM. Most caregivers (84.2%, 101/120) reported that the oncologist had informed them that the patient’s cancer was incurable; however, only 50.9% (58/114) and 53.6% (59/110) of caregivers acknowledged the patient’s cancer was terminal and incurable, respectively. Caregivers of patients undergoing treatment for MM experience substantial psychological distress across the disease continuum, particularly anxiety. The majority of caregivers of patients with MM report that knowing the patient’s prognosis is extremely important and report that the oncologist told them that the patient was incurable. Nevertheless, a significant portion of caregivers believe that the patient’s MM is curable. American Society of Hematology 2022-08-26 /pmc/articles/PMC9631626/ /pubmed/35848842 http://dx.doi.org/10.1182/bloodadvances.2022007127 Text en © 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
spellingShingle Health Services and Outcomes
O’Donnell, Elizabeth K.
Shapiro, Yael N.
Yee, Andrew J.
Nadeem, Omar
Laubach, Jacob P.
Branagan, Andrew R.
Anderson, Kenneth C.
Mo, Clifton C.
Munshi, Nikhil C.
Ghobrial, Irene M.
Sperling, Adam S.
Agyemang, Emerentia A.
Burke, Jill N.
Harrington, Cynthia C.
Hu, Bonnie Y.
Richardson, Paul G.
Raje, Noopur S.
El-Jawahri, Areej
Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
title Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
title_full Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
title_fullStr Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
title_full_unstemmed Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
title_short Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
title_sort quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
topic Health Services and Outcomes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631626/
https://www.ncbi.nlm.nih.gov/pubmed/35848842
http://dx.doi.org/10.1182/bloodadvances.2022007127
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