The VWF binding aptamer rondoraptivon pegol increases platelet counts and VWF/FVIII in type 2B von Willebrand disease

Type 2B von Willebrand disease (VWD) is characterized by an increased binding affinity of von Willebrand factor (VWF) to platelet glycoprotein Ib. This can lead to clearance of high-molecular-weight (HMW) multimers and thrombocytopenia with a resulting moderate-severe bleeding phenotype. Rondoraptiv...

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Detalles Bibliográficos
Autores principales: Ay, Cihan, Pabinger, Ingrid, Kovacevic, Katarina D., Gelbenegger, Georg, Schörgenhofer, Christian, Quehenberger, Peter, Jilma-Stohlawetz, Petra, Sunder-Plassman, Raute, Gilbert, James C., Zhu, Shuhao, Jilma, Bernd, Derhaschnig, Ulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Clinical Trials and Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631691/
https://www.ncbi.nlm.nih.gov/pubmed/35772170
http://dx.doi.org/10.1182/bloodadvances.2022007805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631691/
https://www.ncbi.nlm.nih.gov/pubmed/35772170
http://dx.doi.org/10.1182/bloodadvances.2022007805

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