High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL

Chronic lymphocytic leukemia (CLL) cells have variably low surface IgM (sIgM) levels/signaling capacity, influenced by chronic antigen engagement at tissue sites. Within these low levels, CLL with relatively high sIgM (CLL(high)) progresses more rapidly than CLL with low sIgM (CLL(low)). During ibru...

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Detalles Bibliográficos
Autores principales: Chiodin, Giorgia, Drennan, Samantha, Martino, Enrica A., Ondrisova, Laura, Henderson, Isla, del Rio, Luis, Tracy, Ian, D’Avola, Annalisa, Parker, Helen, Bonfiglio, Silvia, Scarfò, Lydia, Sutton, Lesley-Ann, Strefford, Jonathan C., Forster, Jade, Brake, Oliver, Potter, Kathleen N., Sale, Benjamin, Lanham, Stuart, Mraz, Marek, Ghia, Paolo, Stevenson, Freda K., Forconi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631698/
https://www.ncbi.nlm.nih.gov/pubmed/35640238
http://dx.doi.org/10.1182/bloodadvances.2021006659

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