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Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities

[Image: see text] Three isoindolinone alkaloids (1–3), including one new isoindolinone-type alkaloid, meyeroguilline E (1), and six other known compounds (4–9) were isolated from the poisonous mushroom Chlorophyllum molybdites (Agaricaceae). The structure of the new compound was determined using ext...

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Autores principales: Lee, Bum Soo, Ryoo, Rhim, Park, Jin Song, Choi, Sang Un, Jeong, Se Yun, Ko, Yoon-Joo, Kim, Jung Kyu, Kim, Jin-Chul, Kim, Ki Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631746/
https://www.ncbi.nlm.nih.gov/pubmed/36340132
http://dx.doi.org/10.1021/acsomega.2c06155
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author Lee, Bum Soo
Ryoo, Rhim
Park, Jin Song
Choi, Sang Un
Jeong, Se Yun
Ko, Yoon-Joo
Kim, Jung Kyu
Kim, Jin-Chul
Kim, Ki Hyun
author_facet Lee, Bum Soo
Ryoo, Rhim
Park, Jin Song
Choi, Sang Un
Jeong, Se Yun
Ko, Yoon-Joo
Kim, Jung Kyu
Kim, Jin-Chul
Kim, Ki Hyun
author_sort Lee, Bum Soo
collection PubMed
description [Image: see text] Three isoindolinone alkaloids (1–3), including one new isoindolinone-type alkaloid, meyeroguilline E (1), and six other known compounds (4–9) were isolated from the poisonous mushroom Chlorophyllum molybdites (Agaricaceae). The structure of the new compound was determined using extensive spectroscopic analyses via one-dimensional (1D) and two-dimensional (2D) NMR data interpretation and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). To the best of our knowledge, compound 1 is the first example of a natural isoindolinone with a butanoic acid moiety, and this study is the first to detect the other known compounds (2–9) in C. molybdites. The isolated compounds (1–9) were examined for their multidrug resistance (MDR) reversal activity against MES-SA, MES-SA/DX5, HCT15, and HCT15/CL02 human cancer cells. Based on the results, 20 μM of compounds 3 and 6 slightly potentiated paclitaxel (TAX)-induced cytotoxicity in MES-SA/DX5, HCT15, and HCT15/CL02 cells; however, the compounds had no effect on the cytotoxicity against MES-SA and nonMDR cells.
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spelling pubmed-96317462022-11-04 Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities Lee, Bum Soo Ryoo, Rhim Park, Jin Song Choi, Sang Un Jeong, Se Yun Ko, Yoon-Joo Kim, Jung Kyu Kim, Jin-Chul Kim, Ki Hyun ACS Omega [Image: see text] Three isoindolinone alkaloids (1–3), including one new isoindolinone-type alkaloid, meyeroguilline E (1), and six other known compounds (4–9) were isolated from the poisonous mushroom Chlorophyllum molybdites (Agaricaceae). The structure of the new compound was determined using extensive spectroscopic analyses via one-dimensional (1D) and two-dimensional (2D) NMR data interpretation and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). To the best of our knowledge, compound 1 is the first example of a natural isoindolinone with a butanoic acid moiety, and this study is the first to detect the other known compounds (2–9) in C. molybdites. The isolated compounds (1–9) were examined for their multidrug resistance (MDR) reversal activity against MES-SA, MES-SA/DX5, HCT15, and HCT15/CL02 human cancer cells. Based on the results, 20 μM of compounds 3 and 6 slightly potentiated paclitaxel (TAX)-induced cytotoxicity in MES-SA/DX5, HCT15, and HCT15/CL02 cells; however, the compounds had no effect on the cytotoxicity against MES-SA and nonMDR cells. American Chemical Society 2022-10-24 /pmc/articles/PMC9631746/ /pubmed/36340132 http://dx.doi.org/10.1021/acsomega.2c06155 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Lee, Bum Soo
Ryoo, Rhim
Park, Jin Song
Choi, Sang Un
Jeong, Se Yun
Ko, Yoon-Joo
Kim, Jung Kyu
Kim, Jin-Chul
Kim, Ki Hyun
Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
title Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
title_full Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
title_fullStr Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
title_full_unstemmed Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
title_short Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
title_sort meyeroguilline e, a new isoindolinone alkaloid from the poisonous mushroom chlorophyllum molybdites, and identification of compounds with multidrug resistance (mdr) reversal activities
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631746/
https://www.ncbi.nlm.nih.gov/pubmed/36340132
http://dx.doi.org/10.1021/acsomega.2c06155
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