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Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19

When coronavirus disease 2019 (COVID-19) develops into the severe phase, lung injury, acute respiratory distress syndrome, and/or respiratory failure could develop within a few days. As a result of pulmonary tissue injury, pathomorphological changes usually present endothelial dysfunction, inflammat...

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Autores principales: Huang, Peng, Zhang, Jiahui, Duan, Wenqian, Jiao, Juying, Leng, Aijing, Qu, Jialin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631787/
https://www.ncbi.nlm.nih.gov/pubmed/36339607
http://dx.doi.org/10.3389/fphar.2022.982893
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author Huang, Peng
Zhang, Jiahui
Duan, Wenqian
Jiao, Juying
Leng, Aijing
Qu, Jialin
author_facet Huang, Peng
Zhang, Jiahui
Duan, Wenqian
Jiao, Juying
Leng, Aijing
Qu, Jialin
author_sort Huang, Peng
collection PubMed
description When coronavirus disease 2019 (COVID-19) develops into the severe phase, lung injury, acute respiratory distress syndrome, and/or respiratory failure could develop within a few days. As a result of pulmonary tissue injury, pathomorphological changes usually present endothelial dysfunction, inflammatory cell infiltration of the lung interstitium, defective gas exchange, and wall leakage. Consequently, COVID-19 may progress to tremendous lung injury, ongoing lung failure, and death. Exploring the treatment drugs has important implications. Recently, the application of traditional Chinese medicine had better performance in reducing fatalities, relieving symptoms, and curtailing hospitalization. Through constant research and study, plant polysaccharides may emerge as a crucial resource against lung injury with high potency and low side effects. However, the absence of a comprehensive understanding of lung-protective mechanisms impedes further investigation of polysaccharides. In the present article, a comprehensive review of research into plant polysaccharides in the past 5 years was performed. In total, 30 types of polysaccharides from 19 kinds of plants have shown lung-protective effects through the pathological processes of inflammation, oxidative stress, apoptosis, autophagy, epithelial–mesenchymal transition, and immunomodulation by mediating mucin and aquaporins, macrophage, endoplasmic reticulum stress, neutrophil, TGF-β1 pathways, Nrf2 pathway, and other mechanisms. Moreover, the deficiencies of the current studies and the future research direction are also tentatively discussed. This research provides a comprehensive perspective for better understanding the mechanism and development of polysaccharides against lung injury for the treatment of COVID-19.
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spelling pubmed-96317872022-11-04 Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19 Huang, Peng Zhang, Jiahui Duan, Wenqian Jiao, Juying Leng, Aijing Qu, Jialin Front Pharmacol Pharmacology When coronavirus disease 2019 (COVID-19) develops into the severe phase, lung injury, acute respiratory distress syndrome, and/or respiratory failure could develop within a few days. As a result of pulmonary tissue injury, pathomorphological changes usually present endothelial dysfunction, inflammatory cell infiltration of the lung interstitium, defective gas exchange, and wall leakage. Consequently, COVID-19 may progress to tremendous lung injury, ongoing lung failure, and death. Exploring the treatment drugs has important implications. Recently, the application of traditional Chinese medicine had better performance in reducing fatalities, relieving symptoms, and curtailing hospitalization. Through constant research and study, plant polysaccharides may emerge as a crucial resource against lung injury with high potency and low side effects. However, the absence of a comprehensive understanding of lung-protective mechanisms impedes further investigation of polysaccharides. In the present article, a comprehensive review of research into plant polysaccharides in the past 5 years was performed. In total, 30 types of polysaccharides from 19 kinds of plants have shown lung-protective effects through the pathological processes of inflammation, oxidative stress, apoptosis, autophagy, epithelial–mesenchymal transition, and immunomodulation by mediating mucin and aquaporins, macrophage, endoplasmic reticulum stress, neutrophil, TGF-β1 pathways, Nrf2 pathway, and other mechanisms. Moreover, the deficiencies of the current studies and the future research direction are also tentatively discussed. This research provides a comprehensive perspective for better understanding the mechanism and development of polysaccharides against lung injury for the treatment of COVID-19. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9631787/ /pubmed/36339607 http://dx.doi.org/10.3389/fphar.2022.982893 Text en Copyright © 2022 Huang, Zhang, Duan, Jiao, Leng and Qu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Huang, Peng
Zhang, Jiahui
Duan, Wenqian
Jiao, Juying
Leng, Aijing
Qu, Jialin
Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
title Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
title_full Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
title_fullStr Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
title_full_unstemmed Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
title_short Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
title_sort plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for covid-19
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631787/
https://www.ncbi.nlm.nih.gov/pubmed/36339607
http://dx.doi.org/10.3389/fphar.2022.982893
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