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COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study

BACKGROUND: Heart failure (HF) patients are at higher risk of severe coronavirus disease 2019 (COVID-19). The Omicron variant has many novel mutations including those in the spike protein, leading to questions about vaccine effectiveness. The aim of this analysis was to evaluate the effectiveness of...

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Autores principales: Parenica, Jiri, Benesova, Klara, Radvan, Martin, Sanca, Ondrej, Hlasensky, Jiri, Lokaj, Petr, Ondrus, Tomas, Helanova, Katerina, Kala, Petr, Dusek, Ladislav, Jarkovsky, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631812/
https://www.ncbi.nlm.nih.gov/pubmed/36337877
http://dx.doi.org/10.3389/fcvm.2022.998842
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author Parenica, Jiri
Benesova, Klara
Radvan, Martin
Sanca, Ondrej
Hlasensky, Jiri
Lokaj, Petr
Ondrus, Tomas
Helanova, Katerina
Kala, Petr
Dusek, Ladislav
Jarkovsky, Jiri
author_facet Parenica, Jiri
Benesova, Klara
Radvan, Martin
Sanca, Ondrej
Hlasensky, Jiri
Lokaj, Petr
Ondrus, Tomas
Helanova, Katerina
Kala, Petr
Dusek, Ladislav
Jarkovsky, Jiri
author_sort Parenica, Jiri
collection PubMed
description BACKGROUND: Heart failure (HF) patients are at higher risk of severe coronavirus disease 2019 (COVID-19). The Omicron variant has many novel mutations including those in the spike protein, leading to questions about vaccine effectiveness. The aim of this analysis was to evaluate the effectiveness of the COVID-19 vaccine with or without a booster (i.e., after the third dose) during the Omicron variant wave. METHODS: Chronic heart failure patients in the Czech Republic were included in the analysis. COVID-19 infection was monitored from January 1st 2022 to March 31st 2022. The analysis was conducted on data collected in the National Health Information System. Vaccine effectiveness of vaccinated (with or without booster) vs. unvaccinated patients was analyzed for incidence of COVID-19, COVID-19-related hospitalizations, COVID-19 related intensive care unit admissions, and COVID-19 related mechanical ventilation/extracorporeal membrane oxygenation treatment. FINDINGS: From a total 165,453 HF patients in the Czech Republic, 9,728 contracted COVID-19 (22.9% of them not vaccinated, 23.2% vaccinated and 53.8% vaccinated and boosted). Risk of intensive care unit (ICU) hospitalization was 7.6% in the unvaccinated group, 4.8% in the vaccinated group and 2.9% in the boosted group. The calculated effectiveness of the COVID-19 vaccine in prevention of ICU hospitalization in the vaccinated group was 41.9 and 76.6% in the boosted group. INTERPRETATION: The results demonstrated moderate vaccine effectiveness in the prevention of severe COVID-19 in vaccinated but not boosted HF patients. Much stronger effectiveness was found in those who were vaccinated and boosted.
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spelling pubmed-96318122022-11-04 COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study Parenica, Jiri Benesova, Klara Radvan, Martin Sanca, Ondrej Hlasensky, Jiri Lokaj, Petr Ondrus, Tomas Helanova, Katerina Kala, Petr Dusek, Ladislav Jarkovsky, Jiri Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Heart failure (HF) patients are at higher risk of severe coronavirus disease 2019 (COVID-19). The Omicron variant has many novel mutations including those in the spike protein, leading to questions about vaccine effectiveness. The aim of this analysis was to evaluate the effectiveness of the COVID-19 vaccine with or without a booster (i.e., after the third dose) during the Omicron variant wave. METHODS: Chronic heart failure patients in the Czech Republic were included in the analysis. COVID-19 infection was monitored from January 1st 2022 to March 31st 2022. The analysis was conducted on data collected in the National Health Information System. Vaccine effectiveness of vaccinated (with or without booster) vs. unvaccinated patients was analyzed for incidence of COVID-19, COVID-19-related hospitalizations, COVID-19 related intensive care unit admissions, and COVID-19 related mechanical ventilation/extracorporeal membrane oxygenation treatment. FINDINGS: From a total 165,453 HF patients in the Czech Republic, 9,728 contracted COVID-19 (22.9% of them not vaccinated, 23.2% vaccinated and 53.8% vaccinated and boosted). Risk of intensive care unit (ICU) hospitalization was 7.6% in the unvaccinated group, 4.8% in the vaccinated group and 2.9% in the boosted group. The calculated effectiveness of the COVID-19 vaccine in prevention of ICU hospitalization in the vaccinated group was 41.9 and 76.6% in the boosted group. INTERPRETATION: The results demonstrated moderate vaccine effectiveness in the prevention of severe COVID-19 in vaccinated but not boosted HF patients. Much stronger effectiveness was found in those who were vaccinated and boosted. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9631812/ /pubmed/36337877 http://dx.doi.org/10.3389/fcvm.2022.998842 Text en Copyright © 2022 Parenica, Benesova, Radvan, Sanca, Hlasensky, Lokaj, Ondrus, Helanova, Kala, Dusek and Jarkovsky. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Parenica, Jiri
Benesova, Klara
Radvan, Martin
Sanca, Ondrej
Hlasensky, Jiri
Lokaj, Petr
Ondrus, Tomas
Helanova, Katerina
Kala, Petr
Dusek, Ladislav
Jarkovsky, Jiri
COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study
title COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study
title_full COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study
title_fullStr COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study
title_full_unstemmed COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study
title_short COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study
title_sort covid-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the omicron variant wave: a population-based study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631812/
https://www.ncbi.nlm.nih.gov/pubmed/36337877
http://dx.doi.org/10.3389/fcvm.2022.998842
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