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Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders
Short-chain fatty acids (SCFAs) are metabolites released by bacterial components of the microbiota. These molecules have a wide range of effects in the microbiota itself, but also in host cells in which they are known for contributing to the regulation of cell metabolism, barrier function, and immun...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631819/ https://www.ncbi.nlm.nih.gov/pubmed/36337621 http://dx.doi.org/10.3389/fnut.2022.1011732 |
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author | Corrêa, Renan Oliveira Castro, Pollyana Ribeiro Moser, René Ferreira, Caroline Marcantonio Quesniaux, Valerie F. J. Vinolo, Marco Aurélio Ramirez Ryffel, Bernhard |
author_facet | Corrêa, Renan Oliveira Castro, Pollyana Ribeiro Moser, René Ferreira, Caroline Marcantonio Quesniaux, Valerie F. J. Vinolo, Marco Aurélio Ramirez Ryffel, Bernhard |
author_sort | Corrêa, Renan Oliveira |
collection | PubMed |
description | Short-chain fatty acids (SCFAs) are metabolites released by bacterial components of the microbiota. These molecules have a wide range of effects in the microbiota itself, but also in host cells in which they are known for contributing to the regulation of cell metabolism, barrier function, and immunological responses. Recent studies indicate that these molecules are important players in the gut-lung axis and highlight the possibility of using strategies that alter their intestinal production to prevent or treat distinct lung inflammatory diseases. Here, we review the effects of the SCFA butyrate and its derivatives in vitro and in vivo on murine models of respiratory disorders, besides discussing the potential therapeutic use of butyrate and the other SCFAs in lung diseases. |
format | Online Article Text |
id | pubmed-9631819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96318192022-11-04 Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders Corrêa, Renan Oliveira Castro, Pollyana Ribeiro Moser, René Ferreira, Caroline Marcantonio Quesniaux, Valerie F. J. Vinolo, Marco Aurélio Ramirez Ryffel, Bernhard Front Nutr Nutrition Short-chain fatty acids (SCFAs) are metabolites released by bacterial components of the microbiota. These molecules have a wide range of effects in the microbiota itself, but also in host cells in which they are known for contributing to the regulation of cell metabolism, barrier function, and immunological responses. Recent studies indicate that these molecules are important players in the gut-lung axis and highlight the possibility of using strategies that alter their intestinal production to prevent or treat distinct lung inflammatory diseases. Here, we review the effects of the SCFA butyrate and its derivatives in vitro and in vivo on murine models of respiratory disorders, besides discussing the potential therapeutic use of butyrate and the other SCFAs in lung diseases. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9631819/ /pubmed/36337621 http://dx.doi.org/10.3389/fnut.2022.1011732 Text en Copyright © 2022 Corrêa, Castro, Moser, Ferreira, Quesniaux, Vinolo and Ryffel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Corrêa, Renan Oliveira Castro, Pollyana Ribeiro Moser, René Ferreira, Caroline Marcantonio Quesniaux, Valerie F. J. Vinolo, Marco Aurélio Ramirez Ryffel, Bernhard Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders |
title | Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders |
title_full | Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders |
title_fullStr | Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders |
title_full_unstemmed | Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders |
title_short | Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders |
title_sort | butyrate: connecting the gut-lung axis to the management of pulmonary disorders |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631819/ https://www.ncbi.nlm.nih.gov/pubmed/36337621 http://dx.doi.org/10.3389/fnut.2022.1011732 |
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