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RNA as a Major-Groove Ligand: RNA–RNA and RNA–DNA Triplexes Formed by GAA and UUC or TTC Sequences
[Image: see text] Friedreich’s ataxia is associated with noncanonical nucleic acid structures that emerge when GAA:TTC repeats in the first intron of the FXN gene expand beyond a critical number of repeats. Specifically, the noncanonical repeats are associated with both triplexes and R-loops. Here,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631886/ https://www.ncbi.nlm.nih.gov/pubmed/36340174 http://dx.doi.org/10.1021/acsomega.2c04358 |