Photo-On-Demand Synthesis of α-Amino Acid N-Carboxyanhydrides with Chloroform

[Image: see text] Amino acid N-carboxyanhydrides (NCAs) are conventionally synthesized from α-amino acids and phosgene. The present study reports in situ photo-on-demand phosgenation reactions of amino acids with CHCl(3) for synthesizing NCAs. A series of NCAs were obtained on a gram scale upon phot...

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Detalles Bibliográficos
Autores principales: Sugimoto, Toshiyuki, Kuwahara, Tomoya, Liang, Fengying, Wang, Huirong, Tsuda, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631898/
https://www.ncbi.nlm.nih.gov/pubmed/36340075
http://dx.doi.org/10.1021/acsomega.2c05299
Descripción
Sumario:[Image: see text] Amino acid N-carboxyanhydrides (NCAs) are conventionally synthesized from α-amino acids and phosgene. The present study reports in situ photo-on-demand phosgenation reactions of amino acids with CHCl(3) for synthesizing NCAs. A series of NCAs were obtained on a gram scale upon photo-irradiation of a mixture solution of CHCl(3) and CH(3)CN containing an amino acid at 60–70 °C under O(2) bubbling. This method presents a safe and convenient reaction controlled by light without special apparatuses and reagents.

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