ALAD Inhibition by Porphobilinogen Rationalizes the Accumulation of δ-Aminolevulinate in Acute Porphyrias

[Image: see text] Patients with major forms of acute hepatic porphyria present acute neurological attacks with overproduction of porphobilinogen (PBG) and δ-aminolevulinic acid (ALA). Even if ALA is considered the most likely agent inducing the acute symptoms, the mechanism of its accumulation has n...

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Detalles Bibliográficos
Autores principales: San Juan, Itxaso, Pereira-Ortuzar, Tania, Cendoya, Xabier, Laín, Ana, To-Figueras, Jordi, Mateos, Borja, Planes, Francisco J., Bernardo-Seisdedos, Ganeko, Mato, José M., Millet, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631992/
https://www.ncbi.nlm.nih.gov/pubmed/36241173
http://dx.doi.org/10.1021/acs.biochem.2c00434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631992/
https://www.ncbi.nlm.nih.gov/pubmed/36241173
http://dx.doi.org/10.1021/acs.biochem.2c00434

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