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Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda

BACKGROUND: Malaria and anaemia contribute substantially to child morbidity and mortality. In this study, we sought to jointly model the residual spatial variation in the likelihood of these two correlated diseases, while controlling for individual-level, household-level and environmental characteri...

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Autores principales: Roberts, Danielle J., Zewotir, Temesgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632052/
https://www.ncbi.nlm.nih.gov/pubmed/36329413
http://dx.doi.org/10.1186/s12887-022-03694-4
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author Roberts, Danielle J.
Zewotir, Temesgen
author_facet Roberts, Danielle J.
Zewotir, Temesgen
author_sort Roberts, Danielle J.
collection PubMed
description BACKGROUND: Malaria and anaemia contribute substantially to child morbidity and mortality. In this study, we sought to jointly model the residual spatial variation in the likelihood of these two correlated diseases, while controlling for individual-level, household-level and environmental characteristics. METHODS: A child-level shared component model was utilised to partition shared and disease-specific district-level spatial effects. RESULTS: The results indicated that the spatial variation in the likelihood of malaria was more prominent compared to that of anaemia, for both the shared and specific spatial components. In addition, approximately 30% of the districts were associated with an increased likelihood of anaemia but a decreased likelihood of malaria. This suggests that there are other drivers of anaemia in children in these districts, which warrants further investigation. CONCLUSIONS: The maps of the shared and disease-specific spatial patterns provide a tool to allow for more targeted action in malaria and anaemia control and prevention, as well as for the targeted allocation of limited district health system resources. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03694-4.
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spelling pubmed-96320522022-11-04 Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda Roberts, Danielle J. Zewotir, Temesgen BMC Pediatr Research BACKGROUND: Malaria and anaemia contribute substantially to child morbidity and mortality. In this study, we sought to jointly model the residual spatial variation in the likelihood of these two correlated diseases, while controlling for individual-level, household-level and environmental characteristics. METHODS: A child-level shared component model was utilised to partition shared and disease-specific district-level spatial effects. RESULTS: The results indicated that the spatial variation in the likelihood of malaria was more prominent compared to that of anaemia, for both the shared and specific spatial components. In addition, approximately 30% of the districts were associated with an increased likelihood of anaemia but a decreased likelihood of malaria. This suggests that there are other drivers of anaemia in children in these districts, which warrants further investigation. CONCLUSIONS: The maps of the shared and disease-specific spatial patterns provide a tool to allow for more targeted action in malaria and anaemia control and prevention, as well as for the targeted allocation of limited district health system resources. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03694-4. BioMed Central 2022-11-03 /pmc/articles/PMC9632052/ /pubmed/36329413 http://dx.doi.org/10.1186/s12887-022-03694-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Roberts, Danielle J.
Zewotir, Temesgen
Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda
title Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda
title_full Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda
title_fullStr Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda
title_full_unstemmed Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda
title_short Shared component modelling of early childhood anaemia and malaria in Kenya, Malawi, Tanzania and Uganda
title_sort shared component modelling of early childhood anaemia and malaria in kenya, malawi, tanzania and uganda
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632052/
https://www.ncbi.nlm.nih.gov/pubmed/36329413
http://dx.doi.org/10.1186/s12887-022-03694-4
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