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IL-6 production through repression of UBASH3A gene via epigenetic dysregulation of super-enhancer in CD4(+) T cells in rheumatoid arthritis

BACKGROUND: Rheumatoid arthritis (RA) is associated with immune dysfunction. UBASH3A as a negative regulator of T cell receptors (TCRs) signaling is a susceptible factor in RA. The aim of this study was to determine the role of UBASH3A in RA pathogenesis, by assessing the role of super-enhancer (SE)...

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Detalles Bibliográficos
Autores principales:	Yamagata, Kaoru, Nakayamada, Shingo, Zhang, Tong, Nguyen, Anh Phuong, Ohkubo, Naoyuki, Iwata, Shigeru, Kato, Shigeaki, Tanaka, Yoshiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632101/ https://www.ncbi.nlm.nih.gov/pubmed/36324153 http://dx.doi.org/10.1186/s41232-022-00231-9

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