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Resting state brain subnetwork relates to prosociality and compassion in adolescents

Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental (Do...

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Autores principales: Sipes, Benjamin S., Jakary, Angela, Li, Yi, Max, Jeffrey E., Yang, Tony T., Tymofiyeva, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632179/
https://www.ncbi.nlm.nih.gov/pubmed/36337478
http://dx.doi.org/10.3389/fpsyg.2022.1012745
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author Sipes, Benjamin S.
Jakary, Angela
Li, Yi
Max, Jeffrey E.
Yang, Tony T.
Tymofiyeva, Olga
author_facet Sipes, Benjamin S.
Jakary, Angela
Li, Yi
Max, Jeffrey E.
Yang, Tony T.
Tymofiyeva, Olga
author_sort Sipes, Benjamin S.
collection PubMed
description Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental (Do-GooD) network model of prosocial cognition by relating adolescent functional and structural brain networks with prosocial and compassionate disposition. We acquired resting state fMRI and diffusion MRI from 95 adolescents (ages 14–19  years; 46 males; 49 females) along with self-report questionnaires assessing prosociality and compassion. We then applied the Network-Based Statistic (NBS) to inductively investigate whether there is a significant subnetwork related to prosociality and compassion while controlling for age and sex. Based on the Do-GooD model, we expected that this subnetwork would involve connectivity to the ventromedial prefrontal cortex (VMPFC) from three domain-general networks, the default mode network (DMN), the salience network, and the control network, as well as from the DMN to the mirror neuron systems. NBS revealed a significant functional (but not structural) subnetwork related to prosociality and compassion connecting 31 regions (p = 0.02), showing DMN and DLPFC connectivity to the VMPFC; DMN connectivity to mirror neuron systems; and connectivity between the DMN and cerebellum. These findings largely support and extend the Do-GooD model of prosocial cognition in adolescents by further illuminating network-based relationships that have the potential to advance our understanding of brain mechanisms of prosociality.
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spelling pubmed-96321792022-11-04 Resting state brain subnetwork relates to prosociality and compassion in adolescents Sipes, Benjamin S. Jakary, Angela Li, Yi Max, Jeffrey E. Yang, Tony T. Tymofiyeva, Olga Front Psychol Psychology Adolescence is a crucial time for social development, especially for helping (prosocial) and compassionate behaviors; yet brain networks involved in adolescent prosociality and compassion currently remain underexplored. Here, we sought to evaluate a recently proposed domain-general developmental (Do-GooD) network model of prosocial cognition by relating adolescent functional and structural brain networks with prosocial and compassionate disposition. We acquired resting state fMRI and diffusion MRI from 95 adolescents (ages 14–19  years; 46 males; 49 females) along with self-report questionnaires assessing prosociality and compassion. We then applied the Network-Based Statistic (NBS) to inductively investigate whether there is a significant subnetwork related to prosociality and compassion while controlling for age and sex. Based on the Do-GooD model, we expected that this subnetwork would involve connectivity to the ventromedial prefrontal cortex (VMPFC) from three domain-general networks, the default mode network (DMN), the salience network, and the control network, as well as from the DMN to the mirror neuron systems. NBS revealed a significant functional (but not structural) subnetwork related to prosociality and compassion connecting 31 regions (p = 0.02), showing DMN and DLPFC connectivity to the VMPFC; DMN connectivity to mirror neuron systems; and connectivity between the DMN and cerebellum. These findings largely support and extend the Do-GooD model of prosocial cognition in adolescents by further illuminating network-based relationships that have the potential to advance our understanding of brain mechanisms of prosociality. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9632179/ /pubmed/36337478 http://dx.doi.org/10.3389/fpsyg.2022.1012745 Text en Copyright © 2022 Sipes, Jakary, Li, Max, Yang and Tymofiyeva. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Sipes, Benjamin S.
Jakary, Angela
Li, Yi
Max, Jeffrey E.
Yang, Tony T.
Tymofiyeva, Olga
Resting state brain subnetwork relates to prosociality and compassion in adolescents
title Resting state brain subnetwork relates to prosociality and compassion in adolescents
title_full Resting state brain subnetwork relates to prosociality and compassion in adolescents
title_fullStr Resting state brain subnetwork relates to prosociality and compassion in adolescents
title_full_unstemmed Resting state brain subnetwork relates to prosociality and compassion in adolescents
title_short Resting state brain subnetwork relates to prosociality and compassion in adolescents
title_sort resting state brain subnetwork relates to prosociality and compassion in adolescents
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632179/
https://www.ncbi.nlm.nih.gov/pubmed/36337478
http://dx.doi.org/10.3389/fpsyg.2022.1012745
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