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Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression

Our general purpose was to examine the effect of condensed Fuzheng extract (CFE) on the alleviation of immunosuppression. A mouse model of immunosuppression was established by intraperitoneal injection of CTX. A healthy control group received no CTX and no CFE; different intragastric doses of CFE we...

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Autores principales: Wang, Ji‐Da, Wang, Li, Yu, Shuang, Jin, Yu‐Tong, Wang, Yi‐Yang, Chai, Run‐Dong, Zhao, Ze‐Yu, Bian, Yu‐Hong, Zhao, Shu‐Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632192/
https://www.ncbi.nlm.nih.gov/pubmed/36348791
http://dx.doi.org/10.1002/fsn3.2982
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author Wang, Ji‐Da
Wang, Li
Yu, Shuang
Jin, Yu‐Tong
Wang, Yi‐Yang
Chai, Run‐Dong
Zhao, Ze‐Yu
Bian, Yu‐Hong
Zhao, Shu‐Wu
author_facet Wang, Ji‐Da
Wang, Li
Yu, Shuang
Jin, Yu‐Tong
Wang, Yi‐Yang
Chai, Run‐Dong
Zhao, Ze‐Yu
Bian, Yu‐Hong
Zhao, Shu‐Wu
author_sort Wang, Ji‐Da
collection PubMed
description Our general purpose was to examine the effect of condensed Fuzheng extract (CFE) on the alleviation of immunosuppression. A mouse model of immunosuppression was established by intraperitoneal injection of CTX. A healthy control group received no CTX and no CFE; different intragastric doses of CFE were administered to three groups of mice for 28 days (4500, 2250, or 1125 mg/kg/day); a negative control received CTX alone, and a positive control received CTX and levamisole hydrochloride. We evaluated the effects of CFE on the immune system organs, cells, and molecules by comparing the different groups. CFE significantly improved immune system organs (spleen and thymus indices and histology), stimulated immune cell activities (number of white blood cells and lymphocytes, phagocytosis of mononuclear phagocytes, proliferation of splenic lymphocytes, antibody formation, and NK cell activity), and increased the levels of immunoglobulins (IgA, IgG, and IgM) and cytokines (IL‐2 and IFN‐γ). Thus CFE effectively alleviated CTX‐mediated immunosuppression and oxidative stress and enhanced the immunological functions of mice.
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spelling pubmed-96321922022-11-07 Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression Wang, Ji‐Da Wang, Li Yu, Shuang Jin, Yu‐Tong Wang, Yi‐Yang Chai, Run‐Dong Zhao, Ze‐Yu Bian, Yu‐Hong Zhao, Shu‐Wu Food Sci Nutr Original Articles Our general purpose was to examine the effect of condensed Fuzheng extract (CFE) on the alleviation of immunosuppression. A mouse model of immunosuppression was established by intraperitoneal injection of CTX. A healthy control group received no CTX and no CFE; different intragastric doses of CFE were administered to three groups of mice for 28 days (4500, 2250, or 1125 mg/kg/day); a negative control received CTX alone, and a positive control received CTX and levamisole hydrochloride. We evaluated the effects of CFE on the immune system organs, cells, and molecules by comparing the different groups. CFE significantly improved immune system organs (spleen and thymus indices and histology), stimulated immune cell activities (number of white blood cells and lymphocytes, phagocytosis of mononuclear phagocytes, proliferation of splenic lymphocytes, antibody formation, and NK cell activity), and increased the levels of immunoglobulins (IgA, IgG, and IgM) and cytokines (IL‐2 and IFN‐γ). Thus CFE effectively alleviated CTX‐mediated immunosuppression and oxidative stress and enhanced the immunological functions of mice. John Wiley and Sons Inc. 2022-07-18 /pmc/articles/PMC9632192/ /pubmed/36348791 http://dx.doi.org/10.1002/fsn3.2982 Text en © 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wang, Ji‐Da
Wang, Li
Yu, Shuang
Jin, Yu‐Tong
Wang, Yi‐Yang
Chai, Run‐Dong
Zhao, Ze‐Yu
Bian, Yu‐Hong
Zhao, Shu‐Wu
Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
title Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
title_full Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
title_fullStr Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
title_full_unstemmed Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
title_short Condensed Fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
title_sort condensed fuzheng extract increases immune function in mice with cyclophosphamide‐induced immunosuppression
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632192/
https://www.ncbi.nlm.nih.gov/pubmed/36348791
http://dx.doi.org/10.1002/fsn3.2982
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