Discovery and functional characterization of the oncogenicity and targetability of a novel NOTCH1–ROS1 gene fusion in pediatric angiosarcoma

Angiosarcomas are rare, malignant soft tissue tumors in children that arise in a wide range of anatomical locations and have limited targeted therapies available. Here, we report a rare case of a pediatric angiosarcoma (pAS) with Li–Fraumeni syndrome (LFS) expressing a novel NOTCH1–ROS1 gene fusion....

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Detalles Bibliográficos
Autores principales: Jain, Payal, Iyer, Sudarshan, Straka, Joshua, Surrey, Lea F., Pogoriler, Jennifer, Han, Harry, Smith, Tiffany, Busch, Christine, Fox, Elizabeth, Li, Marilyn, Waanders, Angela J., Resnick, Adam, Davare, Monika A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632357/
https://www.ncbi.nlm.nih.gov/pubmed/36307212
http://dx.doi.org/10.1101/mcs.a006222

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