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Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients

SARS-CoV-2 can be shed in feces and can enter sewage systems. In order to implement effective control measures and identify new channels of transmission, it is essential to identify the presence of infectious virus particles in feces and sewage. In this study, we attempt to utilize Molecular techniq...

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Autores principales: Joshi, Madhuri, Mohandas, Sreelekshmy, Prasad, Sharda, Shinde, Manohar, Chavan, Nutan, Yadav, Pragya D., Lavania, Mallika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632423/
https://www.ncbi.nlm.nih.gov/pubmed/36339137
http://dx.doi.org/10.3389/fpubh.2022.1030249
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author Joshi, Madhuri
Mohandas, Sreelekshmy
Prasad, Sharda
Shinde, Manohar
Chavan, Nutan
Yadav, Pragya D.
Lavania, Mallika
author_facet Joshi, Madhuri
Mohandas, Sreelekshmy
Prasad, Sharda
Shinde, Manohar
Chavan, Nutan
Yadav, Pragya D.
Lavania, Mallika
author_sort Joshi, Madhuri
collection PubMed
description SARS-CoV-2 can be shed in feces and can enter sewage systems. In order to implement effective control measures and identify new channels of transmission, it is essential to identify the presence of infectious virus particles in feces and sewage. In this study, we attempt to utilize Molecular techniques, cell cultures and animal models to find out the infectivity of SARS-CoV-2 in the feces of COVID-19 patients. Our findings exclude the presence of infectious virus particles, suggesting that fecal-oral transmission may not be the main mode of transmission. Larger-scale initiatives are nevertheless required, particularly considering the emergence of new viral strains.
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spelling pubmed-96324232022-11-04 Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients Joshi, Madhuri Mohandas, Sreelekshmy Prasad, Sharda Shinde, Manohar Chavan, Nutan Yadav, Pragya D. Lavania, Mallika Front Public Health Public Health SARS-CoV-2 can be shed in feces and can enter sewage systems. In order to implement effective control measures and identify new channels of transmission, it is essential to identify the presence of infectious virus particles in feces and sewage. In this study, we attempt to utilize Molecular techniques, cell cultures and animal models to find out the infectivity of SARS-CoV-2 in the feces of COVID-19 patients. Our findings exclude the presence of infectious virus particles, suggesting that fecal-oral transmission may not be the main mode of transmission. Larger-scale initiatives are nevertheless required, particularly considering the emergence of new viral strains. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9632423/ /pubmed/36339137 http://dx.doi.org/10.3389/fpubh.2022.1030249 Text en Copyright © 2022 Joshi, Mohandas, Prasad, Shinde, Chavan, Yadav and Lavania. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Joshi, Madhuri
Mohandas, Sreelekshmy
Prasad, Sharda
Shinde, Manohar
Chavan, Nutan
Yadav, Pragya D.
Lavania, Mallika
Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients
title Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients
title_full Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients
title_fullStr Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients
title_full_unstemmed Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients
title_short Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients
title_sort lack of evidence of viability and infectivity of sars-cov-2 in the fecal specimens of covid-19 patients
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632423/
https://www.ncbi.nlm.nih.gov/pubmed/36339137
http://dx.doi.org/10.3389/fpubh.2022.1030249
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