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Sex difference in the expression of PD-1 of non-small cell lung cancer
Evidence increasingly indicated that lung cancer incidence in female individuals continue to rise, and women have a higher risk to develop adenocarcinoma than men. Male and female individuals differ in their innate and adaptive immune responses, and there are sex differences in response to the PD-1/...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632486/ https://www.ncbi.nlm.nih.gov/pubmed/36341395 http://dx.doi.org/10.3389/fimmu.2022.1026214 |
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author | Gu, Yong Tang, Ying Y. Wan, Jian X. Zou, Jian Y. Lu, Chuan G. Zhu, Hao S. Sheng, Si Y. Wang, Yan F. Liu, Hai Ch. Yang, Jia Hong, Hai |
author_facet | Gu, Yong Tang, Ying Y. Wan, Jian X. Zou, Jian Y. Lu, Chuan G. Zhu, Hao S. Sheng, Si Y. Wang, Yan F. Liu, Hai Ch. Yang, Jia Hong, Hai |
author_sort | Gu, Yong |
collection | PubMed |
description | Evidence increasingly indicated that lung cancer incidence in female individuals continue to rise, and women have a higher risk to develop adenocarcinoma than men. Male and female individuals differ in their innate and adaptive immune responses, and there are sex differences in response to the PD-1/PD-L1-dependent blocking immunotherapy. Whether the differential expression of PD-1 between genders affect the response to blocking treatment is currently unknown. In this study, we examined sex differences in serum sPD-1, mPD-1 expression on T cells, and sex hormone levels in non-small cell lung cancer (NSCLC) patients. Our results revealed a higher level of sPD-1 and expression of PD-1 on CD4+T cell in female patients than in male patients; we identified that serum sPD-1 level and the expression of mPD-1 on T cells were significantly reduced in NSCLC; we also found that serum testosterone level increased in female patients compared with control subjects and that increased testosterone downregulated the expression of mPD-1 on T cell. These findings provide a better understanding of the differences in PD-1 expression between genders in NSCLC patients and the effect of sex hormones on PD-1 expression and supply evidence for early lung cancer diagnosis and responsiveness to immune checkpoint inhibitors. |
format | Online Article Text |
id | pubmed-9632486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96324862022-11-04 Sex difference in the expression of PD-1 of non-small cell lung cancer Gu, Yong Tang, Ying Y. Wan, Jian X. Zou, Jian Y. Lu, Chuan G. Zhu, Hao S. Sheng, Si Y. Wang, Yan F. Liu, Hai Ch. Yang, Jia Hong, Hai Front Immunol Immunology Evidence increasingly indicated that lung cancer incidence in female individuals continue to rise, and women have a higher risk to develop adenocarcinoma than men. Male and female individuals differ in their innate and adaptive immune responses, and there are sex differences in response to the PD-1/PD-L1-dependent blocking immunotherapy. Whether the differential expression of PD-1 between genders affect the response to blocking treatment is currently unknown. In this study, we examined sex differences in serum sPD-1, mPD-1 expression on T cells, and sex hormone levels in non-small cell lung cancer (NSCLC) patients. Our results revealed a higher level of sPD-1 and expression of PD-1 on CD4+T cell in female patients than in male patients; we identified that serum sPD-1 level and the expression of mPD-1 on T cells were significantly reduced in NSCLC; we also found that serum testosterone level increased in female patients compared with control subjects and that increased testosterone downregulated the expression of mPD-1 on T cell. These findings provide a better understanding of the differences in PD-1 expression between genders in NSCLC patients and the effect of sex hormones on PD-1 expression and supply evidence for early lung cancer diagnosis and responsiveness to immune checkpoint inhibitors. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9632486/ /pubmed/36341395 http://dx.doi.org/10.3389/fimmu.2022.1026214 Text en Copyright © 2022 Gu, Tang, Wan, Zou, Lu, Zhu, Sheng, Wang, Liu, Yang and Hong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Gu, Yong Tang, Ying Y. Wan, Jian X. Zou, Jian Y. Lu, Chuan G. Zhu, Hao S. Sheng, Si Y. Wang, Yan F. Liu, Hai Ch. Yang, Jia Hong, Hai Sex difference in the expression of PD-1 of non-small cell lung cancer |
title | Sex difference in the expression of PD-1 of non-small cell lung cancer |
title_full | Sex difference in the expression of PD-1 of non-small cell lung cancer |
title_fullStr | Sex difference in the expression of PD-1 of non-small cell lung cancer |
title_full_unstemmed | Sex difference in the expression of PD-1 of non-small cell lung cancer |
title_short | Sex difference in the expression of PD-1 of non-small cell lung cancer |
title_sort | sex difference in the expression of pd-1 of non-small cell lung cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632486/ https://www.ncbi.nlm.nih.gov/pubmed/36341395 http://dx.doi.org/10.3389/fimmu.2022.1026214 |
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