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Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review

BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of...

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Autores principales: Chagas, Stephanye Carolyne Christino, Moreira, Francisca Sueli Monte, Barbosa, Irla Carla França, Leal, Osvaldo de Sousa, Leal, Leila Bastos, de Santana, Davi Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Paulista de Medicina - APM 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632500/
https://www.ncbi.nlm.nih.gov/pubmed/33656132
http://dx.doi.org/10.1590/1516-3180.2020.0532.02112020
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author Chagas, Stephanye Carolyne Christino
Moreira, Francisca Sueli Monte
Barbosa, Irla Carla França
Leal, Osvaldo de Sousa
Leal, Leila Bastos
de Santana, Davi Pereira
author_facet Chagas, Stephanye Carolyne Christino
Moreira, Francisca Sueli Monte
Barbosa, Irla Carla França
Leal, Osvaldo de Sousa
Leal, Leila Bastos
de Santana, Davi Pereira
author_sort Chagas, Stephanye Carolyne Christino
collection PubMed
description BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of cholecalciferol. DESIGN AND SETTING: Narrative review developed by a research group at a public university in Recife (PE), Brazil. METHODS: We searched the literature on the use of cholecalciferol for prevention or treatment of COVID-19, using the MEDLINE and LILACS databases, with the keywords “vitamin D”, “cholecalciferol”, “SARS-CoV-2”, “COVID-19” and “coronavirus”, from January 1, 2020, to June 10, 2020. Narrative reviews, cohort studies and ecological studies were selected. RESULTS: We retrieved 32 references, of which 8 were considered eligible for intensive review and critical analysis. These comprised five narrative reviews, two observational studies and one protocol proposal. Most of the studies selected reported positive effects from use of vitamin D for prevention or treatment of COVID-19. However, there was little quantitative data to assess the real impact of using this vitamin as an intervention against this disease. CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system.
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spelling pubmed-96325002022-11-04 Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review Chagas, Stephanye Carolyne Christino Moreira, Francisca Sueli Monte Barbosa, Irla Carla França Leal, Osvaldo de Sousa Leal, Leila Bastos de Santana, Davi Pereira Sao Paulo Med J Narrative Review BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of cholecalciferol. DESIGN AND SETTING: Narrative review developed by a research group at a public university in Recife (PE), Brazil. METHODS: We searched the literature on the use of cholecalciferol for prevention or treatment of COVID-19, using the MEDLINE and LILACS databases, with the keywords “vitamin D”, “cholecalciferol”, “SARS-CoV-2”, “COVID-19” and “coronavirus”, from January 1, 2020, to June 10, 2020. Narrative reviews, cohort studies and ecological studies were selected. RESULTS: We retrieved 32 references, of which 8 were considered eligible for intensive review and critical analysis. These comprised five narrative reviews, two observational studies and one protocol proposal. Most of the studies selected reported positive effects from use of vitamin D for prevention or treatment of COVID-19. However, there was little quantitative data to assess the real impact of using this vitamin as an intervention against this disease. CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system. Associação Paulista de Medicina - APM 2020-12-24 /pmc/articles/PMC9632500/ /pubmed/33656132 http://dx.doi.org/10.1590/1516-3180.2020.0532.02112020 Text en © 2022 by Associação Paulista de Medicina https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons license.
spellingShingle Narrative Review
Chagas, Stephanye Carolyne Christino
Moreira, Francisca Sueli Monte
Barbosa, Irla Carla França
Leal, Osvaldo de Sousa
Leal, Leila Bastos
de Santana, Davi Pereira
Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_full Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_fullStr Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_full_unstemmed Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_short Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
title_sort critical analysis on the use of cholecalciferol as a covid-19 intervention: a narrative review
topic Narrative Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632500/
https://www.ncbi.nlm.nih.gov/pubmed/33656132
http://dx.doi.org/10.1590/1516-3180.2020.0532.02112020
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