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Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis
BACKGROUND: Despite widespread usage of central blood pressure assessment its predictive value among elderly people remains unclear. OBJECTIVE: To ascertain the capacity of central hemodynamic indices for predicting future all-cause and cardiovascular hard outcomes among elderly people. DESIGN AND S...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Paulista de Medicina - APM
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632515/ https://www.ncbi.nlm.nih.gov/pubmed/33729420 |
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author | Vieceli, Tarsila Brambilla, Bárbara Pereira, Raphael Quintana Dellamea, Bruno Schmidt Stein, Airton Tetelbom Grezzana, Guilherme Brasil |
author_facet | Vieceli, Tarsila Brambilla, Bárbara Pereira, Raphael Quintana Dellamea, Bruno Schmidt Stein, Airton Tetelbom Grezzana, Guilherme Brasil |
author_sort | Vieceli, Tarsila |
collection | PubMed |
description | BACKGROUND: Despite widespread usage of central blood pressure assessment its predictive value among elderly people remains unclear. OBJECTIVE: To ascertain the capacity of central hemodynamic indices for predicting future all-cause and cardiovascular hard outcomes among elderly people. DESIGN AND SETTING: Systematic review and meta-analysis developed at the Del Cuore cardiology clinic, in Antonio Prado, Rio Grande do Sul, Brazil. METHODS: 312 full-text articles were analyzed, from which 35 studies were included for systematic review. The studies included needed to report at least one central hemodynamic index among patients aged 60 years or over. RESULTS: For all-cause mortality, aortic pulse wave velocity (aPWV) and central systolic blood pressure (SBP) were significant, respectively with standardized mean difference (SMD) 0.85 (95% confidence interval, CI 0.69-1.01; I(2) 96%; P < 0.001); and SMD 0.27 (95% CI 0.15-0.39; I(2) 77%; P 0.012). For cardiovascular mortality brachial-ankle PWV (baPWV), central SBP and carotid-femoral PWV (cfPWV) were significant, respectively SMD 0.67 (95% CI 0.40-0.93; I(2) 0%; P 0.610); SMD 0.65 (95% CI 0.48- 0.82; I(2) 80%; P 0.023); and SMD 0.51 (95% CI 0.32-0.69; I(2) 85%; P 0.010). CONCLUSIONS: The meta-analysis results showed that aPWV was promising for predicting all-cause mortality, while baPWV and central SBP demonstrated consistent results in evaluating cardiovascular mortality outcomes. Thus, the findings support usage of central blood pressure as a risk predictor for hard outcomes among elderly people. REGISTRATION NUMBER IN PROSPERO: RD42018085264 |
format | Online Article Text |
id | pubmed-9632515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Associação Paulista de Medicina - APM |
record_format | MEDLINE/PubMed |
spelling | pubmed-96325152022-11-04 Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis Vieceli, Tarsila Brambilla, Bárbara Pereira, Raphael Quintana Dellamea, Bruno Schmidt Stein, Airton Tetelbom Grezzana, Guilherme Brasil Sao Paulo Med J Original Article BACKGROUND: Despite widespread usage of central blood pressure assessment its predictive value among elderly people remains unclear. OBJECTIVE: To ascertain the capacity of central hemodynamic indices for predicting future all-cause and cardiovascular hard outcomes among elderly people. DESIGN AND SETTING: Systematic review and meta-analysis developed at the Del Cuore cardiology clinic, in Antonio Prado, Rio Grande do Sul, Brazil. METHODS: 312 full-text articles were analyzed, from which 35 studies were included for systematic review. The studies included needed to report at least one central hemodynamic index among patients aged 60 years or over. RESULTS: For all-cause mortality, aortic pulse wave velocity (aPWV) and central systolic blood pressure (SBP) were significant, respectively with standardized mean difference (SMD) 0.85 (95% confidence interval, CI 0.69-1.01; I(2) 96%; P < 0.001); and SMD 0.27 (95% CI 0.15-0.39; I(2) 77%; P 0.012). For cardiovascular mortality brachial-ankle PWV (baPWV), central SBP and carotid-femoral PWV (cfPWV) were significant, respectively SMD 0.67 (95% CI 0.40-0.93; I(2) 0%; P 0.610); SMD 0.65 (95% CI 0.48- 0.82; I(2) 80%; P 0.023); and SMD 0.51 (95% CI 0.32-0.69; I(2) 85%; P 0.010). CONCLUSIONS: The meta-analysis results showed that aPWV was promising for predicting all-cause mortality, while baPWV and central SBP demonstrated consistent results in evaluating cardiovascular mortality outcomes. Thus, the findings support usage of central blood pressure as a risk predictor for hard outcomes among elderly people. REGISTRATION NUMBER IN PROSPERO: RD42018085264 Associação Paulista de Medicina - APM 2021-03-12 /pmc/articles/PMC9632515/ /pubmed/33729420 Text en © 2022 by Associação Paulista de Medicina https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons license. |
spellingShingle | Original Article Vieceli, Tarsila Brambilla, Bárbara Pereira, Raphael Quintana Dellamea, Bruno Schmidt Stein, Airton Tetelbom Grezzana, Guilherme Brasil Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
title | Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
title_full | Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
title_fullStr | Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
title_full_unstemmed | Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
title_short | Prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
title_sort | prediction of all-cause and cardiovascular mortality using central hemodynamic indices among elderly people: systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632515/ https://www.ncbi.nlm.nih.gov/pubmed/33729420 |
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