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Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases
BACKGROUND: Serologic testing for autoantibodies is recommended in interstitial lung diseases (ILDs), as connective tissue diseases (CTDs) are an important secondary cause. Myositis antibodies are associated with CTD-ILD, but clinical associations with other ILDs are unclear. In this study, associat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632801/ https://www.ncbi.nlm.nih.gov/pubmed/36327336 http://dx.doi.org/10.1371/journal.pone.0277007 |
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author | Moll, Sofia A. Platenburg, Mark G. J. P. Platteel, Anouk C. M. Vorselaars, Adriane D. M. Janssen Bonàs, Montse Kraaijvanger, Raisa Roodenburg-Benschop, Claudia Meek, Bob van Moorsel, Coline H. M. Grutters, Jan C. |
author_facet | Moll, Sofia A. Platenburg, Mark G. J. P. Platteel, Anouk C. M. Vorselaars, Adriane D. M. Janssen Bonàs, Montse Kraaijvanger, Raisa Roodenburg-Benschop, Claudia Meek, Bob van Moorsel, Coline H. M. Grutters, Jan C. |
author_sort | Moll, Sofia A. |
collection | PubMed |
description | BACKGROUND: Serologic testing for autoantibodies is recommended in interstitial lung diseases (ILDs), as connective tissue diseases (CTDs) are an important secondary cause. Myositis antibodies are associated with CTD-ILD, but clinical associations with other ILDs are unclear. In this study, associations of myositis antibodies in various ILDs were evaluated. METHODS: 1463 ILD patients and 116 healthy subjects were screened for myositis antibodies with a line-blot assay on serum available at time of diagnosis. Additionally, bronchoalveolar lavage fluid (BALf) was analysed. RESULTS: A total of 394 patients demonstrated reactivity to at least one antibody, including anti-Ro52 (36.0%), anti-Mi-2β (17.3%) and anti-Jo-1 (10.9%). Anti-Jo-1 (OR 6.4; p<0.100) and anti-Ro52 (OR 6.0; p<0.001) were associated with CTD-ILD. Interestingly, anti-Mi-2β was associated with idiopathic pulmonary fibrosis (IPF; OR 5.3; p = 0.001) and hypersensitivity pneumonitis (HP; OR 5.9; p<0.001). Furthermore, anti-Mi-2β was strongly associated with a histological usual interstitial pneumonia (UIP) pattern (OR 6.5; p < 0.001). Moreover, anti-Mi-2β reactivity was identified in BALf and correlated with serum anti-Mi-2β (r = 0.64; p = 0.002). No differences were found in survival rates between ILD patients with and without serum Mi-2β reactivity (hazard ratio 0.835; 95% CI 0.442–1.575; p = 0.577). CONCLUSION: In conclusion, novel associations of antibody Mi-2β with fibrotic ILD were found. Furthermore, serum anti-Mi-2β was associated with a histological UIP pattern and presence of anti-Mi-2β in BALf. Possibly, anti-Mi-2β could be implemented as a future diagnostic biomarker for fibrotic ILD. |
format | Online Article Text |
id | pubmed-9632801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-96328012022-11-04 Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases Moll, Sofia A. Platenburg, Mark G. J. P. Platteel, Anouk C. M. Vorselaars, Adriane D. M. Janssen Bonàs, Montse Kraaijvanger, Raisa Roodenburg-Benschop, Claudia Meek, Bob van Moorsel, Coline H. M. Grutters, Jan C. PLoS One Research Article BACKGROUND: Serologic testing for autoantibodies is recommended in interstitial lung diseases (ILDs), as connective tissue diseases (CTDs) are an important secondary cause. Myositis antibodies are associated with CTD-ILD, but clinical associations with other ILDs are unclear. In this study, associations of myositis antibodies in various ILDs were evaluated. METHODS: 1463 ILD patients and 116 healthy subjects were screened for myositis antibodies with a line-blot assay on serum available at time of diagnosis. Additionally, bronchoalveolar lavage fluid (BALf) was analysed. RESULTS: A total of 394 patients demonstrated reactivity to at least one antibody, including anti-Ro52 (36.0%), anti-Mi-2β (17.3%) and anti-Jo-1 (10.9%). Anti-Jo-1 (OR 6.4; p<0.100) and anti-Ro52 (OR 6.0; p<0.001) were associated with CTD-ILD. Interestingly, anti-Mi-2β was associated with idiopathic pulmonary fibrosis (IPF; OR 5.3; p = 0.001) and hypersensitivity pneumonitis (HP; OR 5.9; p<0.001). Furthermore, anti-Mi-2β was strongly associated with a histological usual interstitial pneumonia (UIP) pattern (OR 6.5; p < 0.001). Moreover, anti-Mi-2β reactivity was identified in BALf and correlated with serum anti-Mi-2β (r = 0.64; p = 0.002). No differences were found in survival rates between ILD patients with and without serum Mi-2β reactivity (hazard ratio 0.835; 95% CI 0.442–1.575; p = 0.577). CONCLUSION: In conclusion, novel associations of antibody Mi-2β with fibrotic ILD were found. Furthermore, serum anti-Mi-2β was associated with a histological UIP pattern and presence of anti-Mi-2β in BALf. Possibly, anti-Mi-2β could be implemented as a future diagnostic biomarker for fibrotic ILD. Public Library of Science 2022-11-03 /pmc/articles/PMC9632801/ /pubmed/36327336 http://dx.doi.org/10.1371/journal.pone.0277007 Text en © 2022 Moll et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Moll, Sofia A. Platenburg, Mark G. J. P. Platteel, Anouk C. M. Vorselaars, Adriane D. M. Janssen Bonàs, Montse Kraaijvanger, Raisa Roodenburg-Benschop, Claudia Meek, Bob van Moorsel, Coline H. M. Grutters, Jan C. Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
title | Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
title_full | Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
title_fullStr | Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
title_full_unstemmed | Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
title_short | Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
title_sort | prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632801/ https://www.ncbi.nlm.nih.gov/pubmed/36327336 http://dx.doi.org/10.1371/journal.pone.0277007 |
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