Cargando…
Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
Behçet’s disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifest...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632984/ https://www.ncbi.nlm.nih.gov/pubmed/36341270 http://dx.doi.org/10.3389/fmed.2022.1001120 |
_version_ | 1784824161680490496 |
---|---|
author | Didona, Dario Sequeira Santos, Antonio Manuel Cunha, Tomas Hinterseher, Julia Kussini, Jacqueline Hertl, Michael |
author_facet | Didona, Dario Sequeira Santos, Antonio Manuel Cunha, Tomas Hinterseher, Julia Kussini, Jacqueline Hertl, Michael |
author_sort | Didona, Dario |
collection | PubMed |
description | Behçet’s disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifestations. Serologically, BD is not characterized by disease-specific autoantibodies. In fact, only laboratory markers of inflammation, such as C-reactive protein, may be increased in association with increased disease activity. Bullous pemphigoid (BP) is an autoimmune disease characterized mainly by tense blisters and urticaria-like plaques on the skin. In addition, BP can involve oral mucosa in up to 20% of patients. Patients with BP show serum IgG autoantibodies against BP antigen 180 (BP180) and/or BP antigen 230 (BP230). Tissue-bound autoantibodies can be visualized as linear IgG staining along the basement membrane by direct immunofluorescence microscopy. In this report, we first described a young patient with BD who showed IgG autoantibodies against BP180 without developing blisters or urticaria-like plaques. |
format | Online Article Text |
id | pubmed-9632984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96329842022-11-04 Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease Didona, Dario Sequeira Santos, Antonio Manuel Cunha, Tomas Hinterseher, Julia Kussini, Jacqueline Hertl, Michael Front Med (Lausanne) Medicine Behçet’s disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifestations. Serologically, BD is not characterized by disease-specific autoantibodies. In fact, only laboratory markers of inflammation, such as C-reactive protein, may be increased in association with increased disease activity. Bullous pemphigoid (BP) is an autoimmune disease characterized mainly by tense blisters and urticaria-like plaques on the skin. In addition, BP can involve oral mucosa in up to 20% of patients. Patients with BP show serum IgG autoantibodies against BP antigen 180 (BP180) and/or BP antigen 230 (BP230). Tissue-bound autoantibodies can be visualized as linear IgG staining along the basement membrane by direct immunofluorescence microscopy. In this report, we first described a young patient with BD who showed IgG autoantibodies against BP180 without developing blisters or urticaria-like plaques. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9632984/ /pubmed/36341270 http://dx.doi.org/10.3389/fmed.2022.1001120 Text en Copyright © 2022 Didona, Sequeira Santos, Cunha, Hinterseher, Kussini and Hertl. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Didona, Dario Sequeira Santos, Antonio Manuel Cunha, Tomas Hinterseher, Julia Kussini, Jacqueline Hertl, Michael Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease |
title | Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease |
title_full | Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease |
title_fullStr | Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease |
title_full_unstemmed | Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease |
title_short | Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease |
title_sort | case report: detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with behçet’s disease |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632984/ https://www.ncbi.nlm.nih.gov/pubmed/36341270 http://dx.doi.org/10.3389/fmed.2022.1001120 |
work_keys_str_mv | AT didonadario casereportdetectionofantibullouspemphigoidantigen180antibodiesinapatientwithbehcetsdisease AT sequeirasantosantoniomanuel casereportdetectionofantibullouspemphigoidantigen180antibodiesinapatientwithbehcetsdisease AT cunhatomas casereportdetectionofantibullouspemphigoidantigen180antibodiesinapatientwithbehcetsdisease AT hinterseherjulia casereportdetectionofantibullouspemphigoidantigen180antibodiesinapatientwithbehcetsdisease AT kussinijacqueline casereportdetectionofantibullouspemphigoidantigen180antibodiesinapatientwithbehcetsdisease AT hertlmichael casereportdetectionofantibullouspemphigoidantigen180antibodiesinapatientwithbehcetsdisease |