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Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease

Behçet’s disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifest...

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Autores principales: Didona, Dario, Sequeira Santos, Antonio Manuel, Cunha, Tomas, Hinterseher, Julia, Kussini, Jacqueline, Hertl, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632984/
https://www.ncbi.nlm.nih.gov/pubmed/36341270
http://dx.doi.org/10.3389/fmed.2022.1001120
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author Didona, Dario
Sequeira Santos, Antonio Manuel
Cunha, Tomas
Hinterseher, Julia
Kussini, Jacqueline
Hertl, Michael
author_facet Didona, Dario
Sequeira Santos, Antonio Manuel
Cunha, Tomas
Hinterseher, Julia
Kussini, Jacqueline
Hertl, Michael
author_sort Didona, Dario
collection PubMed
description Behçet’s disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifestations. Serologically, BD is not characterized by disease-specific autoantibodies. In fact, only laboratory markers of inflammation, such as C-reactive protein, may be increased in association with increased disease activity. Bullous pemphigoid (BP) is an autoimmune disease characterized mainly by tense blisters and urticaria-like plaques on the skin. In addition, BP can involve oral mucosa in up to 20% of patients. Patients with BP show serum IgG autoantibodies against BP antigen 180 (BP180) and/or BP antigen 230 (BP230). Tissue-bound autoantibodies can be visualized as linear IgG staining along the basement membrane by direct immunofluorescence microscopy. In this report, we first described a young patient with BD who showed IgG autoantibodies against BP180 without developing blisters or urticaria-like plaques.
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spelling pubmed-96329842022-11-04 Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease Didona, Dario Sequeira Santos, Antonio Manuel Cunha, Tomas Hinterseher, Julia Kussini, Jacqueline Hertl, Michael Front Med (Lausanne) Medicine Behçet’s disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifestations. Serologically, BD is not characterized by disease-specific autoantibodies. In fact, only laboratory markers of inflammation, such as C-reactive protein, may be increased in association with increased disease activity. Bullous pemphigoid (BP) is an autoimmune disease characterized mainly by tense blisters and urticaria-like plaques on the skin. In addition, BP can involve oral mucosa in up to 20% of patients. Patients with BP show serum IgG autoantibodies against BP antigen 180 (BP180) and/or BP antigen 230 (BP230). Tissue-bound autoantibodies can be visualized as linear IgG staining along the basement membrane by direct immunofluorescence microscopy. In this report, we first described a young patient with BD who showed IgG autoantibodies against BP180 without developing blisters or urticaria-like plaques. Frontiers Media S.A. 2022-10-20 /pmc/articles/PMC9632984/ /pubmed/36341270 http://dx.doi.org/10.3389/fmed.2022.1001120 Text en Copyright © 2022 Didona, Sequeira Santos, Cunha, Hinterseher, Kussini and Hertl. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Didona, Dario
Sequeira Santos, Antonio Manuel
Cunha, Tomas
Hinterseher, Julia
Kussini, Jacqueline
Hertl, Michael
Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
title Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
title_full Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
title_fullStr Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
title_full_unstemmed Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
title_short Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet’s disease
title_sort case report: detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with behçet’s disease
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9632984/
https://www.ncbi.nlm.nih.gov/pubmed/36341270
http://dx.doi.org/10.3389/fmed.2022.1001120
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