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Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder

BACKGROUND: A hyperactive default mode network (DMN) has been observed in people with major depressive disorder (MDD), and weak DMN suppression has been linked to depressive symptoms. However, whether dysregulation of the DMN contributes to blunted positive emotional experience in people with MDD is...

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Autores principales: Chao, Zenas C., Dillon, Daniel G., Liu, Yi-Hung, Barrick, Elyssa M., Wu, Chien-Te
Formato: Online Artículo Texto
Lenguaje:English
Publicado: CMA Impact Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633055/
https://www.ncbi.nlm.nih.gov/pubmed/36318983
http://dx.doi.org/10.1503/jpn.220046
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author Chao, Zenas C.
Dillon, Daniel G.
Liu, Yi-Hung
Barrick, Elyssa M.
Wu, Chien-Te
author_facet Chao, Zenas C.
Dillon, Daniel G.
Liu, Yi-Hung
Barrick, Elyssa M.
Wu, Chien-Te
author_sort Chao, Zenas C.
collection PubMed
description BACKGROUND: A hyperactive default mode network (DMN) has been observed in people with major depressive disorder (MDD), and weak DMN suppression has been linked to depressive symptoms. However, whether dysregulation of the DMN contributes to blunted positive emotional experience in people with MDD is unclear. METHODS: We recorded 128-channel electroencephalograms (EEGs) from 24 participants with MDD and 31 healthy controls in a resting state (RS) and an emotion-induction state (ES), in which participants engaged with emotionally positive pictures. We combined Granger causality analysis and data-driven decomposition to extract latent brain networks shared among states and groups, and we further evaluated their interactions across individuals. RESULTS: We extracted 2 subnetworks. Subnetwork 1 represented a delta (δ)–band (1~4 Hz) frontal network that was activated more in the ES than the RS (i.e., task-positive). Subnetwork 2 represented an alpha (α)–band (8~13 Hz) parietal network that was suppressed more in the ES than the RS (i.e., task-negative). These subnetworks were anticorrelated in both the healthy control and MDD groups, but with different sensitivities: for participants with MDD to achieve the same level of task-positive (subnetwork 1) activation as healthy controls, more suppression of task-negative (subnetwork 2) activation was necessary. Furthermore, the anticorrelation strength in participants with MDD correlated with the severity of 2 core MDD symptoms: anhedonia and rumination. LIMITATIONS: The sample size was small. CONCLUSION: Our findings revealed altered coordination between 2 functional networks in MDD and suggest that weak suppression of the task-negative α-band parietal network contributes to blunted positive emotional responses in adults with depression. The subnetworks identified here could be used for diagnosis or targeted for treatment in the future.
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spelling pubmed-96330552022-11-04 Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder Chao, Zenas C. Dillon, Daniel G. Liu, Yi-Hung Barrick, Elyssa M. Wu, Chien-Te J Psychiatry Neurosci Research Paper BACKGROUND: A hyperactive default mode network (DMN) has been observed in people with major depressive disorder (MDD), and weak DMN suppression has been linked to depressive symptoms. However, whether dysregulation of the DMN contributes to blunted positive emotional experience in people with MDD is unclear. METHODS: We recorded 128-channel electroencephalograms (EEGs) from 24 participants with MDD and 31 healthy controls in a resting state (RS) and an emotion-induction state (ES), in which participants engaged with emotionally positive pictures. We combined Granger causality analysis and data-driven decomposition to extract latent brain networks shared among states and groups, and we further evaluated their interactions across individuals. RESULTS: We extracted 2 subnetworks. Subnetwork 1 represented a delta (δ)–band (1~4 Hz) frontal network that was activated more in the ES than the RS (i.e., task-positive). Subnetwork 2 represented an alpha (α)–band (8~13 Hz) parietal network that was suppressed more in the ES than the RS (i.e., task-negative). These subnetworks were anticorrelated in both the healthy control and MDD groups, but with different sensitivities: for participants with MDD to achieve the same level of task-positive (subnetwork 1) activation as healthy controls, more suppression of task-negative (subnetwork 2) activation was necessary. Furthermore, the anticorrelation strength in participants with MDD correlated with the severity of 2 core MDD symptoms: anhedonia and rumination. LIMITATIONS: The sample size was small. CONCLUSION: Our findings revealed altered coordination between 2 functional networks in MDD and suggest that weak suppression of the task-negative α-band parietal network contributes to blunted positive emotional responses in adults with depression. The subnetworks identified here could be used for diagnosis or targeted for treatment in the future. CMA Impact Inc. 2022-11-01 /pmc/articles/PMC9633055/ /pubmed/36318983 http://dx.doi.org/10.1503/jpn.220046 Text en © 2022 CMA Impact Inc. or its licensors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifications or adaptations are made. See: https://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Research Paper
Chao, Zenas C.
Dillon, Daniel G.
Liu, Yi-Hung
Barrick, Elyssa M.
Wu, Chien-Te
Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
title Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
title_full Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
title_fullStr Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
title_full_unstemmed Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
title_short Altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
title_sort altered coordination between frontal delta and parietal alpha networks underlies anhedonia and depressive rumination in major depressive disorder
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633055/
https://www.ncbi.nlm.nih.gov/pubmed/36318983
http://dx.doi.org/10.1503/jpn.220046
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