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Genome-wide base editor screen identifies regulators of protein abundance in yeast

Proteins are key molecular players in a cell, and their abundance is extensively regulated not just at the level of gene expression but also post-transcriptionally. Here, we describe a genetic screen in yeast that enables systematic characterization of how protein abundance regulation is encoded in...

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Detalles Bibliográficos
Autores principales: Schubert, Olga T, Bloom, Joshua S, Sadhu, Meru J, Kruglyak, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633064/
https://www.ncbi.nlm.nih.gov/pubmed/36326816
http://dx.doi.org/10.7554/eLife.79525