Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data

Whether menopausal hormone therapy (MHT) lessens the severity of COVID-19 among women is unclear. Leveraging a U.S. national COVID-19 cohort and a cross-sectional analysis, we found MHT use was marginally associated with a lower risk of mortality (odds ratio [OR] 0.73, 95 % CI 0.53–1.01) and signifi...

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Autores principales: Yoshida, Yilin, Chu, San, Zu, Yuanhao, Fox, Sarah, Mauvais-Jarvis, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633103/
https://www.ncbi.nlm.nih.gov/pubmed/36773498
http://dx.doi.org/10.1016/j.maturitas.2022.10.005
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author Yoshida, Yilin
Chu, San
Zu, Yuanhao
Fox, Sarah
Mauvais-Jarvis, Franck
author_facet Yoshida, Yilin
Chu, San
Zu, Yuanhao
Fox, Sarah
Mauvais-Jarvis, Franck
author_sort Yoshida, Yilin
collection PubMed
description Whether menopausal hormone therapy (MHT) lessens the severity of COVID-19 among women is unclear. Leveraging a U.S. national COVID-19 cohort and a cross-sectional analysis, we found MHT use was marginally associated with a lower risk of mortality (odds ratio [OR] 0.73, 95 % CI 0.53–1.01) and significantly associated with a lower risk of prolonged hospital stay (0.7, 0.49–0.99) among inpatient women. When stratifying by MHT type, estrogen-only and estrogen-plus-progestin therapies had a more prominent protective effect than progestin-only therapy, although this difference did not achieve statistical significance. Women with COVID-19 can continue to use MHT. Clinical trials are needed to evaluate MHT's therapeutic effect on COVID-19, especially in terms of severity.
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spelling pubmed-96331032022-11-04 Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data Yoshida, Yilin Chu, San Zu, Yuanhao Fox, Sarah Mauvais-Jarvis, Franck Maturitas Short Communication Whether menopausal hormone therapy (MHT) lessens the severity of COVID-19 among women is unclear. Leveraging a U.S. national COVID-19 cohort and a cross-sectional analysis, we found MHT use was marginally associated with a lower risk of mortality (odds ratio [OR] 0.73, 95 % CI 0.53–1.01) and significantly associated with a lower risk of prolonged hospital stay (0.7, 0.49–0.99) among inpatient women. When stratifying by MHT type, estrogen-only and estrogen-plus-progestin therapies had a more prominent protective effect than progestin-only therapy, although this difference did not achieve statistical significance. Women with COVID-19 can continue to use MHT. Clinical trials are needed to evaluate MHT's therapeutic effect on COVID-19, especially in terms of severity. Published by Elsevier B.V. 2023-04 2022-11-04 /pmc/articles/PMC9633103/ /pubmed/36773498 http://dx.doi.org/10.1016/j.maturitas.2022.10.005 Text en © 2022 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Yoshida, Yilin
Chu, San
Zu, Yuanhao
Fox, Sarah
Mauvais-Jarvis, Franck
Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data
title Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data
title_full Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data
title_fullStr Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data
title_full_unstemmed Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data
title_short Effect of menopausal hormone therapy on COVID-19 severe outcomes in women – A population-based study of the US National COVID Cohort Collaborative (N3C) data
title_sort effect of menopausal hormone therapy on covid-19 severe outcomes in women – a population-based study of the us national covid cohort collaborative (n3c) data
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633103/
https://www.ncbi.nlm.nih.gov/pubmed/36773498
http://dx.doi.org/10.1016/j.maturitas.2022.10.005
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