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Phase 1 Study to Assess the Safety and Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Subjects Without Cystic Fibrosis With Moderate Hepatic Impairment
BACKGROUND AND OBJECTIVE: Elexacaftor/tezacaftor/ivacaftor is highly effective in treating people with cystic fibrosis (pwCF) who have ≥ 1 responsive mutation. Liver disease occurs in approximately 10%–20% of pwCF. The objective of this study was to assess the safety and pharmacokinetics of elexacaf...
Autores principales: | Viswanathan, Lakshmi, Bachman, Eric, Tian, Simon, Ahluwalia, Neil, Zhang, Yaohua, Bernstein, Harold S., Panorchan, Paul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633523/ https://www.ncbi.nlm.nih.gov/pubmed/36036885 http://dx.doi.org/10.1007/s13318-022-00791-8 |
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