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Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex

Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not fully known. Here we investigated the structure of the salt-and-pepper whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex, in awake mice performing one-vs-all whisker discriminat...

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Autores principales: Wang, Han Chin, LeMessurier, Amy M., Feldman, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633707/
https://www.ncbi.nlm.nih.gov/pubmed/36329010
http://dx.doi.org/10.1038/s41467-022-34261-1
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author Wang, Han Chin
LeMessurier, Amy M.
Feldman, Daniel E.
author_facet Wang, Han Chin
LeMessurier, Amy M.
Feldman, Daniel E.
author_sort Wang, Han Chin
collection PubMed
description Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not fully known. Here we investigated the structure of the salt-and-pepper whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex, in awake mice performing one-vs-all whisker discrimination. Neurons tuned for columnar (CW) and non-columnar (non-CW) whiskers were spatially intermixed, with co-tuned neurons forming local (20 µm) clusters. Whisker tuning was markedly unstable in expert mice, with 35-46% of pyramidal cells significantly shifting tuning over 5-18 days. Tuning instability was highly concentrated in non-CW tuned neurons, and thus was structured in the map. Instability of non-CW neurons was unchanged during chronic whisker paralysis and when mice discriminated individual whiskers, suggesting it is an inherent feature. Thus, L2/3 combines two distinct components: a stable columnar framework of CW-tuned cells that may promote spatial perceptual stability, plus an intermixed, non-columnar surround with highly unstable tuning.
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spelling pubmed-96337072022-11-05 Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex Wang, Han Chin LeMessurier, Amy M. Feldman, Daniel E. Nat Commun Article Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not fully known. Here we investigated the structure of the salt-and-pepper whisker somatotopic map among L2/3 pyramidal neurons in somatosensory cortex, in awake mice performing one-vs-all whisker discrimination. Neurons tuned for columnar (CW) and non-columnar (non-CW) whiskers were spatially intermixed, with co-tuned neurons forming local (20 µm) clusters. Whisker tuning was markedly unstable in expert mice, with 35-46% of pyramidal cells significantly shifting tuning over 5-18 days. Tuning instability was highly concentrated in non-CW tuned neurons, and thus was structured in the map. Instability of non-CW neurons was unchanged during chronic whisker paralysis and when mice discriminated individual whiskers, suggesting it is an inherent feature. Thus, L2/3 combines two distinct components: a stable columnar framework of CW-tuned cells that may promote spatial perceptual stability, plus an intermixed, non-columnar surround with highly unstable tuning. Nature Publishing Group UK 2022-11-03 /pmc/articles/PMC9633707/ /pubmed/36329010 http://dx.doi.org/10.1038/s41467-022-34261-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Han Chin
LeMessurier, Amy M.
Feldman, Daniel E.
Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
title Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
title_full Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
title_fullStr Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
title_full_unstemmed Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
title_short Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
title_sort tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633707/
https://www.ncbi.nlm.nih.gov/pubmed/36329010
http://dx.doi.org/10.1038/s41467-022-34261-1
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