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Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study

INTRODUCTION: Celiac plexus block is effective for treating intractable cancer pain and has been the focus of many studies. Several guiding techniques such as fluoroscopy, computed tomography, and endoscopy have been devised, and the target of the block has varied in previous studies as both the cel...

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Autores principales: Yanaizumi, Ryota, Nagamine, Yusuke, Harada, Shinsuke, Kuramochi, Tomoko, Ota, Shuhei, Abe, Yoichiro, Nakagawa, Masayuki, Kamijima, Kenya, Hayashi, Maya, Tazawa, Toshiharu, Ogawa, Kenichi, Goto, Takahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633912/
https://www.ncbi.nlm.nih.gov/pubmed/36169799
http://dx.doi.org/10.1007/s40122-022-00432-7
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author Yanaizumi, Ryota
Nagamine, Yusuke
Harada, Shinsuke
Kuramochi, Tomoko
Ota, Shuhei
Abe, Yoichiro
Nakagawa, Masayuki
Kamijima, Kenya
Hayashi, Maya
Tazawa, Toshiharu
Ogawa, Kenichi
Goto, Takahisa
author_facet Yanaizumi, Ryota
Nagamine, Yusuke
Harada, Shinsuke
Kuramochi, Tomoko
Ota, Shuhei
Abe, Yoichiro
Nakagawa, Masayuki
Kamijima, Kenya
Hayashi, Maya
Tazawa, Toshiharu
Ogawa, Kenichi
Goto, Takahisa
author_sort Yanaizumi, Ryota
collection PubMed
description INTRODUCTION: Celiac plexus block is effective for treating intractable cancer pain and has been the focus of many studies. Several guiding techniques such as fluoroscopy, computed tomography, and endoscopy have been devised, and the target of the block has varied in previous studies as both the celiac plexus and splanchnic nerve, which is the main origin of the celiac plexus, have been targeted. At our affiliated institution, fluoroscopy-guided splanchnic nerve block with a single needle via transintervertebral disc approach is the first choice. However, there have been few reports on the use of this technique. This study investigated the efficacy and safety of this technique. METHODS: This multicenter retrospective observational study reviewed the medical records of patients who underwent neurolytic splanchnic nerve block (NSNB) via transintervertebral disc approach for intractable cancer pain at five tertiary hospitals in Japan from April 2005 to October 2020. The primary outcome was the clinical success ratio of NSNB, and the secondary outcome was the incidence ratio of NSNB-related adverse events. RESULTS: In total, 103 patients were included in the analysis. Of these, 77 patients met the definition of clinical success, with a ratio of 74.8%. The incidence ratio of NSNB-related adverse events was 40.8% (hypotension, 21.4%; alcohol intoxication, 13.6%; diarrhea, 11.7%; and vascular puncture, 3.9%; duplicates were present). All adverse events improved with observation and symptomatic treatment only. No patient had infection or serious adverse events such as organ or nerve damage. CONCLUSIONS: The clinical success ratio of this technique was 74.8%. Although the incidence of adverse events was 40.8%, all events were mild and no serious adverse events were observed. The findings demonstrate the efficacy and safety of our NSNB in patients with intractable cancer pain.
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spelling pubmed-96339122022-12-07 Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study Yanaizumi, Ryota Nagamine, Yusuke Harada, Shinsuke Kuramochi, Tomoko Ota, Shuhei Abe, Yoichiro Nakagawa, Masayuki Kamijima, Kenya Hayashi, Maya Tazawa, Toshiharu Ogawa, Kenichi Goto, Takahisa Pain Ther Original Research INTRODUCTION: Celiac plexus block is effective for treating intractable cancer pain and has been the focus of many studies. Several guiding techniques such as fluoroscopy, computed tomography, and endoscopy have been devised, and the target of the block has varied in previous studies as both the celiac plexus and splanchnic nerve, which is the main origin of the celiac plexus, have been targeted. At our affiliated institution, fluoroscopy-guided splanchnic nerve block with a single needle via transintervertebral disc approach is the first choice. However, there have been few reports on the use of this technique. This study investigated the efficacy and safety of this technique. METHODS: This multicenter retrospective observational study reviewed the medical records of patients who underwent neurolytic splanchnic nerve block (NSNB) via transintervertebral disc approach for intractable cancer pain at five tertiary hospitals in Japan from April 2005 to October 2020. The primary outcome was the clinical success ratio of NSNB, and the secondary outcome was the incidence ratio of NSNB-related adverse events. RESULTS: In total, 103 patients were included in the analysis. Of these, 77 patients met the definition of clinical success, with a ratio of 74.8%. The incidence ratio of NSNB-related adverse events was 40.8% (hypotension, 21.4%; alcohol intoxication, 13.6%; diarrhea, 11.7%; and vascular puncture, 3.9%; duplicates were present). All adverse events improved with observation and symptomatic treatment only. No patient had infection or serious adverse events such as organ or nerve damage. CONCLUSIONS: The clinical success ratio of this technique was 74.8%. Although the incidence of adverse events was 40.8%, all events were mild and no serious adverse events were observed. The findings demonstrate the efficacy and safety of our NSNB in patients with intractable cancer pain. Springer Healthcare 2022-09-28 2022-12 /pmc/articles/PMC9633912/ /pubmed/36169799 http://dx.doi.org/10.1007/s40122-022-00432-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Yanaizumi, Ryota
Nagamine, Yusuke
Harada, Shinsuke
Kuramochi, Tomoko
Ota, Shuhei
Abe, Yoichiro
Nakagawa, Masayuki
Kamijima, Kenya
Hayashi, Maya
Tazawa, Toshiharu
Ogawa, Kenichi
Goto, Takahisa
Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
title Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
title_full Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
title_fullStr Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
title_full_unstemmed Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
title_short Efficacy and Safety of Neurolytic Splanchnic Nerve Block via Transintervertebral Disc Approach to Retrocrural Space: A Multicenter Retrospective Study
title_sort efficacy and safety of neurolytic splanchnic nerve block via transintervertebral disc approach to retrocrural space: a multicenter retrospective study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633912/
https://www.ncbi.nlm.nih.gov/pubmed/36169799
http://dx.doi.org/10.1007/s40122-022-00432-7
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