Triple drug therapy with GABA, sitagliptin, and omeprazole prevents type 1 diabetes onset and promotes its reversal in non-obese diabetic mice

Previous studies have reported that dual drug combinations consisting of γ-aminobutyric acid (GABA) together with a dipeptidyl-peptidase-4 inhibitor (DPP-4i), also a DPP-4i with a proton pump inhibitor (PPI), could improve pancreatic β-cell function and ameliorate diabetes in diabetic mice. In this...

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Detalles Bibliográficos
Autores principales: Lagunas-Rangel, Francisco Alejandro, Koshelev, Daniil, Nedorubov, Andrej, Kosheleva, Liudmila, Trukhan, Vladimir, Rabinovitch, Alexander, Schiöth, Helgi B., Levit, Shmuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9633961/
https://www.ncbi.nlm.nih.gov/pubmed/36339443
http://dx.doi.org/10.3389/fendo.2022.1028114

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