New lesion segmentation for multiple sclerosis brain images with imaging and lesion-aware augmentation

Multiple sclerosis (MS) is an inflammatory and demyelinating neurological disease of the central nervous system. Image-based biomarkers, such as lesions defined on magnetic resonance imaging (MRI), play an important role in MS diagnosis and patient monitoring. The detection of newly formed lesions provides crucial information for assessing disease progression and treatment outcome. Here, we propose a deep learning-based pipeline for new MS lesion detection and segmentation, which is built upon the nnU-Net framework. In addition to conventional data augmentation, we employ imaging and lesion-aware data augmentation methods, axial subsampling and CarveMix, to generate diverse samples and improve segmentation performance. The proposed pipeline is evaluated on the MICCAI 2021 MS new lesion segmentation challenge (MSSEG-2) dataset. It achieves an average Dice score of 0.510 and F(1) score of 0.552 on cases with new lesions, and an average false positive lesion number n(FP) of 0.036 and false positive lesion volume V(FP) of 0.192 mm(3) on cases with no new lesions. Our method outperforms other participating methods in the challenge and several state-of-the-art network architectures.