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Epidemiologic study on gestational trophoblastic diseases in Japan

OBJECTIVE: This study aims to estimate the population-based incidence of gestational trophoblastic diseases (GTDs) and to identify the characteristics of gestational trophoblastic neoplasia (GTN) in Japan. METHODS: The annual number of GTD and live births from 1974 to 2018 were used to estimate the...

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Autores principales: Yamamoto, Eiko, Nishino, Kimihiro, Niimi, Kaoru, Ino, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634103/
https://www.ncbi.nlm.nih.gov/pubmed/36047375
http://dx.doi.org/10.3802/jgo.2022.33.e72
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author Yamamoto, Eiko
Nishino, Kimihiro
Niimi, Kaoru
Ino, Kazuhiko
author_facet Yamamoto, Eiko
Nishino, Kimihiro
Niimi, Kaoru
Ino, Kazuhiko
author_sort Yamamoto, Eiko
collection PubMed
description OBJECTIVE: This study aims to estimate the population-based incidence of gestational trophoblastic diseases (GTDs) and to identify the characteristics of gestational trophoblastic neoplasia (GTN) in Japan. METHODS: The annual number of GTD and live births from 1974 to 2018 were used to estimate the incidence of GTD. The data of 1,574 GTN cases from 1999 to 2018 were analyzed to identify the characteristics of low-risk GTN, high-risk GTN, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). RESULTS: The incidence of hydatidiform mole was 2.02 per 1,000 live births on average which decreased from 1974 to 2008 and increased from 2009 to 2018. The incidence of low-risk GTN, high-risk GTN, PSTT, and ETT was 15.3, 3.5, 0.3, and 0.07 per 100,000 live births, respectively. The estimated incidence of post-molar GTN was 9.8% of molar patients. High-risk GTN was diagnosed more pathologically, had more various kinds of antecedent pregnancies, and had longer intervals after the antecedent pregnancy compared to low-risk GTN. Furthermore, 8.2% of high-risk GTN occurred after the subsequent non-molar pregnancy of hydatidiform mole. The cumulative percentage of developing high-risk GTN after hydatidiform mole reached 89.3% at the 60th month. CONCLUSION: The incidence of hydatidiform mole, low-risk GTN, high-risk GTN was 2.02 per 1,000 live births, 15.3 per 100,000 live births, and 3.5 per 100,000 live births, respectively. High-risk GTN was diagnosed more pathologically and later after the antecedent pregnancy than low-risk GTN. Following molar patients for five years is needed to improve the mortality of malignant GTN.
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spelling pubmed-96341032022-11-14 Epidemiologic study on gestational trophoblastic diseases in Japan Yamamoto, Eiko Nishino, Kimihiro Niimi, Kaoru Ino, Kazuhiko J Gynecol Oncol Original Article OBJECTIVE: This study aims to estimate the population-based incidence of gestational trophoblastic diseases (GTDs) and to identify the characteristics of gestational trophoblastic neoplasia (GTN) in Japan. METHODS: The annual number of GTD and live births from 1974 to 2018 were used to estimate the incidence of GTD. The data of 1,574 GTN cases from 1999 to 2018 were analyzed to identify the characteristics of low-risk GTN, high-risk GTN, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). RESULTS: The incidence of hydatidiform mole was 2.02 per 1,000 live births on average which decreased from 1974 to 2008 and increased from 2009 to 2018. The incidence of low-risk GTN, high-risk GTN, PSTT, and ETT was 15.3, 3.5, 0.3, and 0.07 per 100,000 live births, respectively. The estimated incidence of post-molar GTN was 9.8% of molar patients. High-risk GTN was diagnosed more pathologically, had more various kinds of antecedent pregnancies, and had longer intervals after the antecedent pregnancy compared to low-risk GTN. Furthermore, 8.2% of high-risk GTN occurred after the subsequent non-molar pregnancy of hydatidiform mole. The cumulative percentage of developing high-risk GTN after hydatidiform mole reached 89.3% at the 60th month. CONCLUSION: The incidence of hydatidiform mole, low-risk GTN, high-risk GTN was 2.02 per 1,000 live births, 15.3 per 100,000 live births, and 3.5 per 100,000 live births, respectively. High-risk GTN was diagnosed more pathologically and later after the antecedent pregnancy than low-risk GTN. Following molar patients for five years is needed to improve the mortality of malignant GTN. Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology 2022-08-10 /pmc/articles/PMC9634103/ /pubmed/36047375 http://dx.doi.org/10.3802/jgo.2022.33.e72 Text en © 2022. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yamamoto, Eiko
Nishino, Kimihiro
Niimi, Kaoru
Ino, Kazuhiko
Epidemiologic study on gestational trophoblastic diseases in Japan
title Epidemiologic study on gestational trophoblastic diseases in Japan
title_full Epidemiologic study on gestational trophoblastic diseases in Japan
title_fullStr Epidemiologic study on gestational trophoblastic diseases in Japan
title_full_unstemmed Epidemiologic study on gestational trophoblastic diseases in Japan
title_short Epidemiologic study on gestational trophoblastic diseases in Japan
title_sort epidemiologic study on gestational trophoblastic diseases in japan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634103/
https://www.ncbi.nlm.nih.gov/pubmed/36047375
http://dx.doi.org/10.3802/jgo.2022.33.e72
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