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Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases

Kidney disease is one of the leading non-communicable diseases related to tremendous health and economic burden globally. Diabetes, hypertension, obesity and cardiovascular conditions are the major risk factors for kidney disease, followed by infections, toxicity and autoimmune causes. The peroxisom...

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Autores principales: Sharma, Vinesh, Patial, Vikram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634118/
https://www.ncbi.nlm.nih.gov/pubmed/36339586
http://dx.doi.org/10.3389/fphar.2022.991059
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author Sharma, Vinesh
Patial, Vikram
author_facet Sharma, Vinesh
Patial, Vikram
author_sort Sharma, Vinesh
collection PubMed
description Kidney disease is one of the leading non-communicable diseases related to tremendous health and economic burden globally. Diabetes, hypertension, obesity and cardiovascular conditions are the major risk factors for kidney disease, followed by infections, toxicity and autoimmune causes. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-activated nuclear receptor that plays an essential role in kidney physiology and disease. The synthetic agonists of PPAR-γ shows a therapeutic effect in various kidney conditions; however, the associated side effect restricts their use. Therefore, there is an increasing interest in exploring natural products with PPARγ-activating potential, which can be a promising solution to developing effective and safe treatment of kidney diseases. In this review, we have discussed the role of PPAR-γ in the pathophysiology of kidney disease and the potential of natural PPAR-γ agonists in treating various kidney diseases, including acute kidney injury, diabetic kidney disease, obesity-induced nephropathy, hypertension nephropathy and IgA nephropathy. PPAR-γ is a potential target for the natural PPAR-γ agonists against kidney disease; however, more studies are required in this direction.
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spelling pubmed-96341182022-11-05 Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases Sharma, Vinesh Patial, Vikram Front Pharmacol Pharmacology Kidney disease is one of the leading non-communicable diseases related to tremendous health and economic burden globally. Diabetes, hypertension, obesity and cardiovascular conditions are the major risk factors for kidney disease, followed by infections, toxicity and autoimmune causes. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-activated nuclear receptor that plays an essential role in kidney physiology and disease. The synthetic agonists of PPAR-γ shows a therapeutic effect in various kidney conditions; however, the associated side effect restricts their use. Therefore, there is an increasing interest in exploring natural products with PPARγ-activating potential, which can be a promising solution to developing effective and safe treatment of kidney diseases. In this review, we have discussed the role of PPAR-γ in the pathophysiology of kidney disease and the potential of natural PPAR-γ agonists in treating various kidney diseases, including acute kidney injury, diabetic kidney disease, obesity-induced nephropathy, hypertension nephropathy and IgA nephropathy. PPAR-γ is a potential target for the natural PPAR-γ agonists against kidney disease; however, more studies are required in this direction. Frontiers Media S.A. 2022-10-21 /pmc/articles/PMC9634118/ /pubmed/36339586 http://dx.doi.org/10.3389/fphar.2022.991059 Text en Copyright © 2022 Sharma and Patial. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Sharma, Vinesh
Patial, Vikram
Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
title Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
title_full Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
title_fullStr Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
title_full_unstemmed Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
title_short Peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
title_sort peroxisome proliferator-activated receptor gamma and its natural agonists in the treatment of kidney diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634118/
https://www.ncbi.nlm.nih.gov/pubmed/36339586
http://dx.doi.org/10.3389/fphar.2022.991059
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