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Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study

OBJECTIVE: To identify the relationship between telomere length and the prognosis of breast cancer with different status of estrogen receptor (ER). METHODS: We collected single nucleotide polymorphisms (SNPs) associated with telomere length and breast cancer prognosis from the MRCIEU GWAS database a...

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Autores principales: Li, Yilun, Ma, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634263/
https://www.ncbi.nlm.nih.gov/pubmed/36338739
http://dx.doi.org/10.3389/fonc.2022.1024772
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author Li, Yilun
Ma, Li
author_facet Li, Yilun
Ma, Li
author_sort Li, Yilun
collection PubMed
description OBJECTIVE: To identify the relationship between telomere length and the prognosis of breast cancer with different status of estrogen receptor (ER). METHODS: We collected single nucleotide polymorphisms (SNPs) associated with telomere length and breast cancer prognosis from the MRCIEU GWAS database and the dataset of a large meta-analysis conducted by the Breast Cancer Association Consortium (BCAC), respectively. The relationship was identified using inverse-variance weighted (IVW), MR-Egger, weighted median, penalized weighted median, and maximum likelihood methods. IVW, MR-Egger, and MR-PRESSO methods were used to perform sensitivity analysis to assess the accuracy of the results. RESULTS: Telomere length was negatively associated with the prognosis of total breast cancer (odds ratio [OR]=1.84, 95% confidence interval [CI]=1.08-3.14, IVW method), especially with ER- breast cancer (OR=1.89, 95% CI=1.11-3.22, IVW method). No similar relationship was found between telomere length and the prognosis of ER+ breast cancer (OR=0.99, 95% CI=0.62-1.58, IVW method). The findings from other methods were consistent with the results shown by the IVW method. The Mendelian randomization assumptions did not appear to be violated. Sensitivity analysis indicated that the result was robust, and no bias was observed in the study. CONCLUSION: Telomere length is associated with the prognosis of total breast cancer, especially with ER- breast cancer. There is no significant correlation between telomere length and the prognosis of ER+ breast cancer. These findings add to the evidence that long telomere could predict a poor prognosis of ER- breast cancer.
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spelling pubmed-96342632022-11-05 Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study Li, Yilun Ma, Li Front Oncol Oncology OBJECTIVE: To identify the relationship between telomere length and the prognosis of breast cancer with different status of estrogen receptor (ER). METHODS: We collected single nucleotide polymorphisms (SNPs) associated with telomere length and breast cancer prognosis from the MRCIEU GWAS database and the dataset of a large meta-analysis conducted by the Breast Cancer Association Consortium (BCAC), respectively. The relationship was identified using inverse-variance weighted (IVW), MR-Egger, weighted median, penalized weighted median, and maximum likelihood methods. IVW, MR-Egger, and MR-PRESSO methods were used to perform sensitivity analysis to assess the accuracy of the results. RESULTS: Telomere length was negatively associated with the prognosis of total breast cancer (odds ratio [OR]=1.84, 95% confidence interval [CI]=1.08-3.14, IVW method), especially with ER- breast cancer (OR=1.89, 95% CI=1.11-3.22, IVW method). No similar relationship was found between telomere length and the prognosis of ER+ breast cancer (OR=0.99, 95% CI=0.62-1.58, IVW method). The findings from other methods were consistent with the results shown by the IVW method. The Mendelian randomization assumptions did not appear to be violated. Sensitivity analysis indicated that the result was robust, and no bias was observed in the study. CONCLUSION: Telomere length is associated with the prognosis of total breast cancer, especially with ER- breast cancer. There is no significant correlation between telomere length and the prognosis of ER+ breast cancer. These findings add to the evidence that long telomere could predict a poor prognosis of ER- breast cancer. Frontiers Media S.A. 2022-10-21 /pmc/articles/PMC9634263/ /pubmed/36338739 http://dx.doi.org/10.3389/fonc.2022.1024772 Text en Copyright © 2022 Li and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Yilun
Ma, Li
Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
title Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
title_full Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
title_fullStr Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
title_full_unstemmed Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
title_short Relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: A Mendelian randomization study
title_sort relationship between telomere length and the prognosis of breast cancer based on estrogen receptor status: a mendelian randomization study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634263/
https://www.ncbi.nlm.nih.gov/pubmed/36338739
http://dx.doi.org/10.3389/fonc.2022.1024772
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