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Influence of hypomagnetic field on the heartbeat in zebrafish embryos

The magnetic environment may influence the functioning of the cardiovascular system. It was reported that low-frequency and static magnetic fields affect hemodynamics, heart rate, and heart rate variability in animals and humans. Moreover, recent data suggest that magnetic fields affect the circadia...

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Autores principales: Krylov, Viacheslav, Machikhin, Alexander, Sizov, Daniil, Guryleva, Anastasia, Sizova, Anastasia, Zhdanova, Svetlana, Tchougounov, Vladimir, Burlakov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634549/
https://www.ncbi.nlm.nih.gov/pubmed/36338501
http://dx.doi.org/10.3389/fphys.2022.1040083
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author Krylov, Viacheslav
Machikhin, Alexander
Sizov, Daniil
Guryleva, Anastasia
Sizova, Anastasia
Zhdanova, Svetlana
Tchougounov, Vladimir
Burlakov, Alexander
author_facet Krylov, Viacheslav
Machikhin, Alexander
Sizov, Daniil
Guryleva, Anastasia
Sizova, Anastasia
Zhdanova, Svetlana
Tchougounov, Vladimir
Burlakov, Alexander
author_sort Krylov, Viacheslav
collection PubMed
description The magnetic environment may influence the functioning of the cardiovascular system. It was reported that low-frequency and static magnetic fields affect hemodynamics, heart rate, and heart rate variability in animals and humans. Moreover, recent data suggest that magnetic fields affect the circadian rhythms of physiological processes. The influence of the magnetic environment on heart functionating during early development has been studied insufficiently. We utilized transparent zebrafish embryos to evaluate the effect of the hypomagnetic field on the characteristics of cardiac function using a noninvasive optical approach based on photoplethysmographic microscopic imaging. The embryos were exposed to the geomagnetic and hypomagnetic fields from the second to the 116th hour post fertilization under a 16 h light/8 h dark cycle or constant illumination. The exposure of embryos to the hypomagnetic field in both lighting modes led to increased embryo mortality, the appearance of abnormal phenotypes, and a significant increase in the embryo’s heartbeat rate. The difference between maximal and minimal heartbeat intervals, maximal to minimal heartbeat intervals ratio, and the coefficient of variation of heartbeat rate were increased in the embryos exposed to the hypomagnetic field under constant illumination from 96 to 116 h post fertilization. The dynamics of heartbeat rate changes followed a circadian pattern in all studied groups except zebrafish exposed to the hypomagnetic field under constant illumination. The results demonstrate the importance of natural magnetic background for the early development of zebrafish. The possible mechanisms of observed effects are discussed.
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spelling pubmed-96345492022-11-05 Influence of hypomagnetic field on the heartbeat in zebrafish embryos Krylov, Viacheslav Machikhin, Alexander Sizov, Daniil Guryleva, Anastasia Sizova, Anastasia Zhdanova, Svetlana Tchougounov, Vladimir Burlakov, Alexander Front Physiol Physiology The magnetic environment may influence the functioning of the cardiovascular system. It was reported that low-frequency and static magnetic fields affect hemodynamics, heart rate, and heart rate variability in animals and humans. Moreover, recent data suggest that magnetic fields affect the circadian rhythms of physiological processes. The influence of the magnetic environment on heart functionating during early development has been studied insufficiently. We utilized transparent zebrafish embryos to evaluate the effect of the hypomagnetic field on the characteristics of cardiac function using a noninvasive optical approach based on photoplethysmographic microscopic imaging. The embryos were exposed to the geomagnetic and hypomagnetic fields from the second to the 116th hour post fertilization under a 16 h light/8 h dark cycle or constant illumination. The exposure of embryos to the hypomagnetic field in both lighting modes led to increased embryo mortality, the appearance of abnormal phenotypes, and a significant increase in the embryo’s heartbeat rate. The difference between maximal and minimal heartbeat intervals, maximal to minimal heartbeat intervals ratio, and the coefficient of variation of heartbeat rate were increased in the embryos exposed to the hypomagnetic field under constant illumination from 96 to 116 h post fertilization. The dynamics of heartbeat rate changes followed a circadian pattern in all studied groups except zebrafish exposed to the hypomagnetic field under constant illumination. The results demonstrate the importance of natural magnetic background for the early development of zebrafish. The possible mechanisms of observed effects are discussed. Frontiers Media S.A. 2022-10-21 /pmc/articles/PMC9634549/ /pubmed/36338501 http://dx.doi.org/10.3389/fphys.2022.1040083 Text en Copyright © 2022 Krylov, Machikhin, Sizov, Guryleva, Sizova, Zhdanova, Tchougounov and Burlakov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Krylov, Viacheslav
Machikhin, Alexander
Sizov, Daniil
Guryleva, Anastasia
Sizova, Anastasia
Zhdanova, Svetlana
Tchougounov, Vladimir
Burlakov, Alexander
Influence of hypomagnetic field on the heartbeat in zebrafish embryos
title Influence of hypomagnetic field on the heartbeat in zebrafish embryos
title_full Influence of hypomagnetic field on the heartbeat in zebrafish embryos
title_fullStr Influence of hypomagnetic field on the heartbeat in zebrafish embryos
title_full_unstemmed Influence of hypomagnetic field on the heartbeat in zebrafish embryos
title_short Influence of hypomagnetic field on the heartbeat in zebrafish embryos
title_sort influence of hypomagnetic field on the heartbeat in zebrafish embryos
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634549/
https://www.ncbi.nlm.nih.gov/pubmed/36338501
http://dx.doi.org/10.3389/fphys.2022.1040083
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