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Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines,...

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Autores principales: Zhong, Wang-Jing, Ma, Lingdi, Yang, Fanfan, Cao, Jialin, Tan, Junyu, Li, Bohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634663/
https://www.ncbi.nlm.nih.gov/pubmed/36339620
http://dx.doi.org/10.3389/fphar.2022.1027441
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author Zhong, Wang-Jing
Ma, Lingdi
Yang, Fanfan
Cao, Jialin
Tan, Junyu
Li, Bohong
author_facet Zhong, Wang-Jing
Ma, Lingdi
Yang, Fanfan
Cao, Jialin
Tan, Junyu
Li, Bohong
author_sort Zhong, Wang-Jing
collection PubMed
description Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines, and matrine inhibited both transcription and translation of c-Myc. Ribosome biogenesis and nucleotide metabolism, the key downstream of c-Myc, were significantly suppressed after matrine treatment. Therefore, our results confirmed that matrine is a special c-Myc inhibitor which suppresses ribosome biogenesis and nucleotide metabolism by inhibiting c-Myc in myeloid leukemia. This study provides scientific basis for the development of matrine derivatives to c-Myc-driven cancers.
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spelling pubmed-96346632022-11-05 Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia Zhong, Wang-Jing Ma, Lingdi Yang, Fanfan Cao, Jialin Tan, Junyu Li, Bohong Front Pharmacol Pharmacology Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines, and matrine inhibited both transcription and translation of c-Myc. Ribosome biogenesis and nucleotide metabolism, the key downstream of c-Myc, were significantly suppressed after matrine treatment. Therefore, our results confirmed that matrine is a special c-Myc inhibitor which suppresses ribosome biogenesis and nucleotide metabolism by inhibiting c-Myc in myeloid leukemia. This study provides scientific basis for the development of matrine derivatives to c-Myc-driven cancers. Frontiers Media S.A. 2022-10-21 /pmc/articles/PMC9634663/ /pubmed/36339620 http://dx.doi.org/10.3389/fphar.2022.1027441 Text en Copyright © 2022 Zhong, Ma, Yang, Cao, Tan and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhong, Wang-Jing
Ma, Lingdi
Yang, Fanfan
Cao, Jialin
Tan, Junyu
Li, Bohong
Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
title Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
title_full Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
title_fullStr Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
title_full_unstemmed Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
title_short Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
title_sort matrine, a potential c-myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634663/
https://www.ncbi.nlm.nih.gov/pubmed/36339620
http://dx.doi.org/10.3389/fphar.2022.1027441
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