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Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines,...

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Detalles Bibliográficos
Autores principales: Zhong, Wang-Jing, Ma, Lingdi, Yang, Fanfan, Cao, Jialin, Tan, Junyu, Li, Bohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634663/
https://www.ncbi.nlm.nih.gov/pubmed/36339620
http://dx.doi.org/10.3389/fphar.2022.1027441

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