Cargando…
Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis
Puberty is a critical phase of life associated with physiological changes related to sexual maturation, and represents a complex process regulated by multiple endocrine and genetic controls. Puberty is driven by hormones, and it can impact the gut microbiome (GM). GM differences between sex emerge a...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634744/ https://www.ncbi.nlm.nih.gov/pubmed/36339428 http://dx.doi.org/10.3389/fendo.2022.1000919 |
_version_ | 1784824562824773632 |
---|---|
author | Calcaterra, Valeria Rossi, Virginia Massini, Giulia Regalbuto, Corrado Hruby, Chiara Panelli, Simona Bandi, Claudio Zuccotti, Gianvincenzo |
author_facet | Calcaterra, Valeria Rossi, Virginia Massini, Giulia Regalbuto, Corrado Hruby, Chiara Panelli, Simona Bandi, Claudio Zuccotti, Gianvincenzo |
author_sort | Calcaterra, Valeria |
collection | PubMed |
description | Puberty is a critical phase of life associated with physiological changes related to sexual maturation, and represents a complex process regulated by multiple endocrine and genetic controls. Puberty is driven by hormones, and it can impact the gut microbiome (GM). GM differences between sex emerge at puberty onset, confirming a relationship between microbiota and sex hormones. In this narrative review, we present an overview of precocious pubertal development and the changes in the GM in precocious puberty (PP) in order to consider the role of the sex hormone–gut microbiome axis from the perspective of pediatric endocrinology. Bidirectional interactions between the GM and sex hormones have been proposed in different studies. Although the evidence on the interaction between microbiota and sex hormones remains limited in pediatric patients, the evidence that GM alterations may occur in girls with central precocious puberty (CPP) represents an interesting finding for the prediction and prevention of PP. Deepening the understanding of the connection between the sex hormones and the role of microbiota changes can lead to the implementation of microbiota-targeted therapies in pubertal disorders by offering a pediatric endocrinology perspective. |
format | Online Article Text |
id | pubmed-9634744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96347442022-11-05 Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis Calcaterra, Valeria Rossi, Virginia Massini, Giulia Regalbuto, Corrado Hruby, Chiara Panelli, Simona Bandi, Claudio Zuccotti, Gianvincenzo Front Endocrinol (Lausanne) Endocrinology Puberty is a critical phase of life associated with physiological changes related to sexual maturation, and represents a complex process regulated by multiple endocrine and genetic controls. Puberty is driven by hormones, and it can impact the gut microbiome (GM). GM differences between sex emerge at puberty onset, confirming a relationship between microbiota and sex hormones. In this narrative review, we present an overview of precocious pubertal development and the changes in the GM in precocious puberty (PP) in order to consider the role of the sex hormone–gut microbiome axis from the perspective of pediatric endocrinology. Bidirectional interactions between the GM and sex hormones have been proposed in different studies. Although the evidence on the interaction between microbiota and sex hormones remains limited in pediatric patients, the evidence that GM alterations may occur in girls with central precocious puberty (CPP) represents an interesting finding for the prediction and prevention of PP. Deepening the understanding of the connection between the sex hormones and the role of microbiota changes can lead to the implementation of microbiota-targeted therapies in pubertal disorders by offering a pediatric endocrinology perspective. Frontiers Media S.A. 2022-10-21 /pmc/articles/PMC9634744/ /pubmed/36339428 http://dx.doi.org/10.3389/fendo.2022.1000919 Text en Copyright © 2022 Calcaterra, Rossi, Massini, Regalbuto, Hruby, Panelli, Bandi and Zuccotti https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Calcaterra, Valeria Rossi, Virginia Massini, Giulia Regalbuto, Corrado Hruby, Chiara Panelli, Simona Bandi, Claudio Zuccotti, Gianvincenzo Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis |
title | Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis |
title_full | Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis |
title_fullStr | Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis |
title_full_unstemmed | Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis |
title_short | Precocious puberty and microbiota: The role of the sex hormone–gut microbiome axis |
title_sort | precocious puberty and microbiota: the role of the sex hormone–gut microbiome axis |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634744/ https://www.ncbi.nlm.nih.gov/pubmed/36339428 http://dx.doi.org/10.3389/fendo.2022.1000919 |
work_keys_str_mv | AT calcaterravaleria precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT rossivirginia precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT massinigiulia precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT regalbutocorrado precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT hrubychiara precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT panellisimona precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT bandiclaudio precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis AT zuccottigianvincenzo precociouspubertyandmicrobiotatheroleofthesexhormonegutmicrobiomeaxis |