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Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice

BACKGROUND AND AIMS: Acute liver failure (ALF) is associated with high mortality. Gasdermin D (GSDMD) is the executioner of pyroptosis and is involved in the pathophysiology of immune dysregulation This study investigated the role of the GSDMD inhibitor necrosulfonamide (NSA) in ALF. METHODS: An ALF...

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Detalles Bibliográficos
Autores principales:	Wu, Yi-Long, Ou, Wei-Jie, Zhong, Ming, Lin, Su, Zhu, Yue-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	XIA & HE Publishing Inc. 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634782/ https://www.ncbi.nlm.nih.gov/pubmed/36381100 http://dx.doi.org/10.14218/JCTH.2021.00560

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