Cargando…
Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis
BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Paulista de Medicina - APM
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634837/ https://www.ncbi.nlm.nih.gov/pubmed/34586287 http://dx.doi.org/10.1590/1516-3180.2020.0799.R1.0904221 |
_version_ | 1784824584528199680 |
---|---|
author | Lucchetta, Rosa Camila Cavicchioli, Sophia de Andrade Gini, Ana Luísa Rodriguez Forgerini, Marcela Varallo, Fabiana Rossi de Nadai, Mariane Nunes Fernandez-Llimos, Fernando Mastroianni, Patricia de Carvalho |
author_facet | Lucchetta, Rosa Camila Cavicchioli, Sophia de Andrade Gini, Ana Luísa Rodriguez Forgerini, Marcela Varallo, Fabiana Rossi de Nadai, Mariane Nunes Fernandez-Llimos, Fernando Mastroianni, Patricia de Carvalho |
author_sort | Lucchetta, Rosa Camila |
collection | PubMed |
description | BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil. DESIGN AND SETTING: Systematic review and meta-analysis conducted at a Brazilian public university. METHODS: A search from index inception until May 2020 was conducted. Meta-analyses were performed using inverse variance for fixed models, with summary proportions calculation using Freeman-Tukey double arcsine (base case). Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. RESULTS: Our review identified 12 studies, comprising 1,316 participants, especially breastfeeding women. There was at least one quality weakness in all studies, mainly regarding sampling method (i.e. convenience sampling) and small sample size. The prevalence of vitamin C deficiency ranged from 0% to 40%. Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. The cumulative meta-analysis suggested that a trend to lower prevalence of vitamin E deficiency occurred in recent studies. CONCLUSIONS: Although the studies identified in this systematic review had poor methodological and reporting quality, mild-moderate vitamin C and E deficiencies were identified, especially in breastfeeding women. Thus, designing and implementing policies does not seem to be a priority, because the need has not been properly dimensioned among women of childbearing age in Brazil. REGISTRATION NUMBER IN PROSPERO: CRD42020221605. |
format | Online Article Text |
id | pubmed-9634837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Associação Paulista de Medicina - APM |
record_format | MEDLINE/PubMed |
spelling | pubmed-96348372022-11-04 Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis Lucchetta, Rosa Camila Cavicchioli, Sophia de Andrade Gini, Ana Luísa Rodriguez Forgerini, Marcela Varallo, Fabiana Rossi de Nadai, Mariane Nunes Fernandez-Llimos, Fernando Mastroianni, Patricia de Carvalho Sao Paulo Med J Original Article BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil. DESIGN AND SETTING: Systematic review and meta-analysis conducted at a Brazilian public university. METHODS: A search from index inception until May 2020 was conducted. Meta-analyses were performed using inverse variance for fixed models, with summary proportions calculation using Freeman-Tukey double arcsine (base case). Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. RESULTS: Our review identified 12 studies, comprising 1,316 participants, especially breastfeeding women. There was at least one quality weakness in all studies, mainly regarding sampling method (i.e. convenience sampling) and small sample size. The prevalence of vitamin C deficiency ranged from 0% to 40%. Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. The cumulative meta-analysis suggested that a trend to lower prevalence of vitamin E deficiency occurred in recent studies. CONCLUSIONS: Although the studies identified in this systematic review had poor methodological and reporting quality, mild-moderate vitamin C and E deficiencies were identified, especially in breastfeeding women. Thus, designing and implementing policies does not seem to be a priority, because the need has not been properly dimensioned among women of childbearing age in Brazil. REGISTRATION NUMBER IN PROSPERO: CRD42020221605. Associação Paulista de Medicina - APM 2021-03-18 /pmc/articles/PMC9634837/ /pubmed/34586287 http://dx.doi.org/10.1590/1516-3180.2020.0799.R1.0904221 Text en © 2022 by Associação Paulista de Medicina https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons license. |
spellingShingle | Original Article Lucchetta, Rosa Camila Cavicchioli, Sophia de Andrade Gini, Ana Luísa Rodriguez Forgerini, Marcela Varallo, Fabiana Rossi de Nadai, Mariane Nunes Fernandez-Llimos, Fernando Mastroianni, Patricia de Carvalho Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis |
title | Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis |
title_full | Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis |
title_fullStr | Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis |
title_full_unstemmed | Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis |
title_short | Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis |
title_sort | deficiency of vitamins c and e in women of childbearing age in brazil: a systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634837/ https://www.ncbi.nlm.nih.gov/pubmed/34586287 http://dx.doi.org/10.1590/1516-3180.2020.0799.R1.0904221 |
work_keys_str_mv | AT lucchettarosacamila deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT cavicchiolisophiadeandrade deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT ginianaluisarodriguez deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT forgerinimarcela deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT varallofabianarossi deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT denadaimarianenunes deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT fernandezllimosfernando deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis AT mastroiannipatriciadecarvalho deficiencyofvitaminscandeinwomenofchildbearingageinbrazilasystematicreviewandmetaanalysis |