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Clinical Features of Children with COVID-19 Infection: Single-Center Experience

Objective: Compared to adult studies, there are few epidemiological and clinical reports on coronavirus disease 2019 in children. We aimed to present the demographic, epidemiological, and clinical findings of hospitalized pediatric coronavirus disease 2019 patients. Materials and Methods: Patients a...

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Autores principales: Guler, Muhammet Akif, Laloglu, Fuat, Orbak, Zerrin, Ceviz, Naci, Islek, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Atatürk University School of Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634880/
https://www.ncbi.nlm.nih.gov/pubmed/35703526
http://dx.doi.org/10.5152/eurasianjmed.2022.21083
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author Guler, Muhammet Akif
Laloglu, Fuat
Orbak, Zerrin
Ceviz, Naci
Islek, Ali
author_facet Guler, Muhammet Akif
Laloglu, Fuat
Orbak, Zerrin
Ceviz, Naci
Islek, Ali
author_sort Guler, Muhammet Akif
collection PubMed
description Objective: Compared to adult studies, there are few epidemiological and clinical reports on coronavirus disease 2019 in children. We aimed to present the demographic, epidemiological, and clinical findings of hospitalized pediatric coronavirus disease 2019 patients. Materials and Methods: Patients aged 0–18 years who were hospitalized between March and July 2020 due to severe acute respiratory syndrome coronavirus 2 infection were evaluated retrospectively. Results: The mean age was 90.2 ± 67.5 (7–24) months and 23 (51%) were female. Clinical presentation was asymptomatic in 15 cases (33.3%), mild/moderate in 26 cases (57.8%), and severe/critical in 4 cases (8.9%). Three (6.6%) of the patients had chronic medical conditions that placed them in the high-risk group for coronavirus disease 2019. The source of infection was household transmission in 29 cases (64.4%). The most common symptoms were cough, fever, and fatigue. Mean serum lactate, C-reactive protein (CRP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were significantly higher in severe/critical patients compared to the other two groups (P < .05). severe acute respiratory syndrome coronavirus 2 negativity in control swabs (n=26) occurred at a mean of 10.6 ± 2.9 days after symptom onset. Forty-three patients (95.6%) were followed in the ward and 2 (4.4%) were admitted to the intensive care unit. Conclusion: Children aged 0–18 years constituted a very small proportion of coronavirus disease 2019 reverse transcription-polymerase chain reaction -positive cases. Asymptomatic carriage of SARS-CoV-2 by a large proportion of children seems to be a major factor driving community spread. Some children with coronavirus disease 2019 may also present neurological findings. coronavirus disease 2019 infection is more severe in patients with comorbidities, and support therapy is important in these patients.
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spelling pubmed-96348802022-11-04 Clinical Features of Children with COVID-19 Infection: Single-Center Experience Guler, Muhammet Akif Laloglu, Fuat Orbak, Zerrin Ceviz, Naci Islek, Ali Eurasian J Med Original Article Objective: Compared to adult studies, there are few epidemiological and clinical reports on coronavirus disease 2019 in children. We aimed to present the demographic, epidemiological, and clinical findings of hospitalized pediatric coronavirus disease 2019 patients. Materials and Methods: Patients aged 0–18 years who were hospitalized between March and July 2020 due to severe acute respiratory syndrome coronavirus 2 infection were evaluated retrospectively. Results: The mean age was 90.2 ± 67.5 (7–24) months and 23 (51%) were female. Clinical presentation was asymptomatic in 15 cases (33.3%), mild/moderate in 26 cases (57.8%), and severe/critical in 4 cases (8.9%). Three (6.6%) of the patients had chronic medical conditions that placed them in the high-risk group for coronavirus disease 2019. The source of infection was household transmission in 29 cases (64.4%). The most common symptoms were cough, fever, and fatigue. Mean serum lactate, C-reactive protein (CRP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were significantly higher in severe/critical patients compared to the other two groups (P < .05). severe acute respiratory syndrome coronavirus 2 negativity in control swabs (n=26) occurred at a mean of 10.6 ± 2.9 days after symptom onset. Forty-three patients (95.6%) were followed in the ward and 2 (4.4%) were admitted to the intensive care unit. Conclusion: Children aged 0–18 years constituted a very small proportion of coronavirus disease 2019 reverse transcription-polymerase chain reaction -positive cases. Asymptomatic carriage of SARS-CoV-2 by a large proportion of children seems to be a major factor driving community spread. Some children with coronavirus disease 2019 may also present neurological findings. coronavirus disease 2019 infection is more severe in patients with comorbidities, and support therapy is important in these patients. Atatürk University School of Medicine 2022-06-01 /pmc/articles/PMC9634880/ /pubmed/35703526 http://dx.doi.org/10.5152/eurasianjmed.2022.21083 Text en © Copyright 2022 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Guler, Muhammet Akif
Laloglu, Fuat
Orbak, Zerrin
Ceviz, Naci
Islek, Ali
Clinical Features of Children with COVID-19 Infection: Single-Center Experience
title Clinical Features of Children with COVID-19 Infection: Single-Center Experience
title_full Clinical Features of Children with COVID-19 Infection: Single-Center Experience
title_fullStr Clinical Features of Children with COVID-19 Infection: Single-Center Experience
title_full_unstemmed Clinical Features of Children with COVID-19 Infection: Single-Center Experience
title_short Clinical Features of Children with COVID-19 Infection: Single-Center Experience
title_sort clinical features of children with covid-19 infection: single-center experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9634880/
https://www.ncbi.nlm.nih.gov/pubmed/35703526
http://dx.doi.org/10.5152/eurasianjmed.2022.21083
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